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Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons

Schuppe, Hansjürgen and Newland, Philip L. (2004) Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons Journal of Neurobiology, 59, (3), pp. 331-342. (doi:10.1002/neu.10333).

Record type: Article

Abstract

In crayfish, movement of the tailfan causes stimulation of exteroceptive sensory hairs located on its surface. Movement is monitored by a proprioceptor, the protopodite-endopodite chordotonal organ within the tailfan. Proprioceptive afferents provide indirect presynaptic inhibitory inputs to sensory hair afferents in the form of primary afferent depolarizations (PADs). Bath application of nitric oxide (NO) substrates, donors and scavengers, and nitric oxide synthase (NOS) inhibitors had no effect on the responses of proprioceptive afferents during imposed movements of the chordotonal organ. In contrast, the amplitude of PADs in exteroceptive hair afferents was dependent on NO levels. NO levels were altered by bath-application of the NOprecursor L-arginine, the NO donor SNAP, the NOSinhibitor L-NAME, and the NO scavenger PTIO, while changes in PAD amplitude were measured. Application of L-arginine or SNAP resulted in consistent decreases in PAD amplitude, whereas L-NAME and PTIO induced increases in PAD amplitude. These results suggest that endogenous NO decreases inhibitory inputs to exteroceptive neurons, thus enhancing transmitter release at their output synapses.

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More information

Published date: June 2004
Keywords: neuromodulation, presynaptic inhibition, local circuit, reflex, crayfish

Identifiers

Local EPrints ID: 24212
URI: http://eprints.soton.ac.uk/id/eprint/24212
ISSN: 0022-3034
PURE UUID: fcf03127-f8d0-49fb-9763-065522be26c3

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Date deposited: 28 Mar 2006
Last modified: 17 Jul 2017 16:14

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Contributors

Author: Hansjürgen Schuppe

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