Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons

Schuppe, Hansjürgen and Newland, Philip L. (2004) Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons Journal of Neurobiology, 59, (3), pp. 331-342. (doi:10.1002/neu.10333).


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In crayfish, movement of the tailfan causes stimulation of exteroceptive sensory hairs located on its surface. Movement is monitored by a proprioceptor, the protopodite-endopodite chordotonal organ within the tailfan. Proprioceptive afferents provide indirect presynaptic inhibitory inputs to sensory hair afferents in the form of primary afferent depolarizations (PADs). Bath application of nitric oxide (NO) substrates, donors and scavengers, and nitric oxide synthase (NOS) inhibitors had no effect on the responses of proprioceptive afferents during imposed movements of the chordotonal organ. In contrast, the amplitude of PADs in exteroceptive hair afferents was dependent on NO levels. NO levels were altered by bath-application of the NOprecursor L-arginine, the NO donor SNAP, the NOSinhibitor L-NAME, and the NO scavenger PTIO, while changes in PAD amplitude were measured. Application of L-arginine or SNAP resulted in consistent decreases in PAD amplitude, whereas L-NAME and PTIO induced increases in PAD amplitude. These results suggest that endogenous NO decreases inhibitory inputs to exteroceptive neurons, thus enhancing transmitter release at their output synapses.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/neu.10333
ISSNs: 0022-3034 (print)
Related URLs:
Keywords: neuromodulation, presynaptic inhibition, local circuit, reflex, crayfish
ePrint ID: 24212
Date :
Date Event
June 2004Published
Date Deposited: 28 Mar 2006
Last Modified: 16 Apr 2017 22:41
Further Information:Google Scholar

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