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Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring

Butler, Janet A., Peveler, Robert C., Roderick, Paul, Horne, Robert and Mason, Juan C. (2004) Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring Transplantation, 77, (5), pp. 786-789.

Record type: Article

Abstract

Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine levels. The sensitivity and specificity of these measures were determined by comparison with electronic monitoring in a randomly selected subsample of 58 subjects. Measures of adherence in current clinical use do not perform well when tested against electronic monitoring. Self-report at a confidential interview was the best measure of adherence for the detection of both missed doses and erratic timing of medication. However, the use of a confidential interview is not directly applicable to a clinical setting. Further research on how best to facilitate disclosure in clinical settings may be the best way to develop adherence measures for use in routine practice.

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Published date: 2004

Identifiers

Local EPrints ID: 24287
URI: http://eprints.soton.ac.uk/id/eprint/24287
ISSN: 0041-1337
PURE UUID: 0dcd129b-52e4-4e1b-9ab1-c24b9f15abde
ORCID for Robert C. Peveler: ORCID iD orcid.org/0000-0001-5596-9394
ORCID for Paul Roderick: ORCID iD orcid.org/0000-0001-9475-6850

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 17 Jul 2017 16:14

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Contributors

Author: Janet A. Butler
Author: Paul Roderick ORCID iD
Author: Robert Horne
Author: Juan C. Mason

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