The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Estimating kidney function in adults using formulae

Estimating kidney function in adults using formulae
Estimating kidney function in adults using formulae
With increasing emphasis on the earlier detection and management of chronic kidney disease (CKD), estimation of the glomerular filtration rate (GFR) has assumed greater importance. It is accepted that use of serum creatinine concentration alone as a marker of kidney function is inadequate; in particular, it has a poor sensitivity for detecting CKD. International recommendations favour the reporting of creatinine-based estimates of GFR using formulae which also take into account age, gender and other variables that affect the relationship between serum creatinine and GFR: in particular, the four-variable formula derived from the Modification of Diet in Renal Disease study (4-v MDRD) is increasingly being used. We have reviewed the literature supporting the use of this formula compared with the well-established Cockcroft and Gault formula. Overall, evidence supports the use of the 4-v MDRD formula as an improved estimate of GFR in people with moderate/advanced CKD. Neither formula performs well in people with normal and mildly reduced kidney function. However, there remain significant problems with this approach and areas where further research is required. In particular, the widespread adoption of estimated GFR reporting has refocused attention on the limitations of creatinine measurement and highlighted clinical situations in which the formulae are inadequate.
0004-5632
321-345
Lamb, Edmund J.
321b2cb0-d081-46c9-ae5d-17595999eb6e
Tomson, Charles R.V.
becceeb5-d43f-478f-b848-5ce30fd8caad
Roderick, Paul J.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Lamb, Edmund J.
321b2cb0-d081-46c9-ae5d-17595999eb6e
Tomson, Charles R.V.
becceeb5-d43f-478f-b848-5ce30fd8caad
Roderick, Paul J.
dbb3cd11-4c51-4844-982b-0eb30ad5085a

Lamb, Edmund J., Tomson, Charles R.V. and Roderick, Paul J. (2005) Estimating kidney function in adults using formulae. Annals of Clinical Biochemistry, 42 (5), 321-345. (doi:10.1258/0004563054889936).

Record type: Article

Abstract

With increasing emphasis on the earlier detection and management of chronic kidney disease (CKD), estimation of the glomerular filtration rate (GFR) has assumed greater importance. It is accepted that use of serum creatinine concentration alone as a marker of kidney function is inadequate; in particular, it has a poor sensitivity for detecting CKD. International recommendations favour the reporting of creatinine-based estimates of GFR using formulae which also take into account age, gender and other variables that affect the relationship between serum creatinine and GFR: in particular, the four-variable formula derived from the Modification of Diet in Renal Disease study (4-v MDRD) is increasingly being used. We have reviewed the literature supporting the use of this formula compared with the well-established Cockcroft and Gault formula. Overall, evidence supports the use of the 4-v MDRD formula as an improved estimate of GFR in people with moderate/advanced CKD. Neither formula performs well in people with normal and mildly reduced kidney function. However, there remain significant problems with this approach and areas where further research is required. In particular, the widespread adoption of estimated GFR reporting has refocused attention on the limitations of creatinine measurement and highlighted clinical situations in which the formulae are inadequate.

This record has no associated files available for download.

More information

Published date: 2005
Additional Information: Review Article

Identifiers

Local EPrints ID: 24367
URI: http://eprints.soton.ac.uk/id/eprint/24367
ISSN: 0004-5632
PURE UUID: f55de413-910a-4620-8993-0a78f52aa271
ORCID for Paul J. Roderick: ORCID iD orcid.org/0000-0001-9475-6850

Catalogue record

Date deposited: 30 Mar 2006
Last modified: 09 Jan 2022 02:47

Export record

Altmetrics

Contributors

Author: Edmund J. Lamb
Author: Charles R.V. Tomson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×