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Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential

Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential
Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential
Extracts of the secondary roots of the southern African plant, Devil’s Claw (Harpagophytum procumbens) provide a herbal drug with a variety of traditional indications. One area of its use that has become very popular in recent years is in the treatment of inflammatory disorders of the musculoskeletal system and of low back pain. There have been several clinical studies recently published that generally support its use in treating osteoarthritis although more studies are required in order to establish this drug as a definite therapeutic option. Here in this review, the pharmacological properties of Devil’s Claw are reviewed in detail and the clinical evidence is briefly summarised. There is good in vitro and in vivo pharmacological evidence of the anti-inflammatory and analgesic properties of this drug, although some negative findings have also been reported. Generally, the pharmacological properties of Devil’s Claw is supportive of its therapeutic potential, but more evidence from clinically relevant models, as well as at the cellular and molecular level, should be sought. Such studies may provide evidence in support of additional indications, both traditional and novel. The clinical data on Devil’s Claw is also very promising.
analgesic, anti-inflammatory, devil's claw, harpagophytum procumbens, osteoarthritis
1568-7767
47 -53
McGregor, Gerard
9500e6f0-0cfb-484d-85d5-1777f21d64c5
Fiebich, Bernd
b26be222-5649-486c-8795-0cafce8d48ec
Wartenberg, Andrea
11f6a116-695c-46fb-a101-dae41a7537f8
Brien, Sarah
4e8e97cd-7bc3-4efd-857e-20790040b80f
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Wegener, Tankred
4938405f-bd62-4ccb-a8b2-79b6932f4262
McGregor, Gerard
9500e6f0-0cfb-484d-85d5-1777f21d64c5
Fiebich, Bernd
b26be222-5649-486c-8795-0cafce8d48ec
Wartenberg, Andrea
11f6a116-695c-46fb-a101-dae41a7537f8
Brien, Sarah
4e8e97cd-7bc3-4efd-857e-20790040b80f
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Wegener, Tankred
4938405f-bd62-4ccb-a8b2-79b6932f4262

McGregor, Gerard, Fiebich, Bernd, Wartenberg, Andrea, Brien, Sarah, Lewith, George and Wegener, Tankred (2005) Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential. Phytochemistry Reviews, 4 (1), 47 -53. (doi:10.1007/s11101-004-2374-8).

Record type: Article

Abstract

Extracts of the secondary roots of the southern African plant, Devil’s Claw (Harpagophytum procumbens) provide a herbal drug with a variety of traditional indications. One area of its use that has become very popular in recent years is in the treatment of inflammatory disorders of the musculoskeletal system and of low back pain. There have been several clinical studies recently published that generally support its use in treating osteoarthritis although more studies are required in order to establish this drug as a definite therapeutic option. Here in this review, the pharmacological properties of Devil’s Claw are reviewed in detail and the clinical evidence is briefly summarised. There is good in vitro and in vivo pharmacological evidence of the anti-inflammatory and analgesic properties of this drug, although some negative findings have also been reported. Generally, the pharmacological properties of Devil’s Claw is supportive of its therapeutic potential, but more evidence from clinically relevant models, as well as at the cellular and molecular level, should be sought. Such studies may provide evidence in support of additional indications, both traditional and novel. The clinical data on Devil’s Claw is also very promising.

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More information

Published date: 2005
Keywords: analgesic, anti-inflammatory, devil's claw, harpagophytum procumbens, osteoarthritis

Identifiers

Local EPrints ID: 24422
URI: http://eprints.soton.ac.uk/id/eprint/24422
ISSN: 1568-7767
PURE UUID: 1783a93a-f7b2-4d1a-8dc1-61d069ae48fb

Catalogue record

Date deposited: 29 Mar 2006
Last modified: 09 Jan 2022 06:04

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Contributors

Author: Gerard McGregor
Author: Bernd Fiebich
Author: Andrea Wartenberg
Author: Sarah Brien
Author: George Lewith
Author: Tankred Wegener

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