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Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential

McGregor, Gerard, Fiebich, Bernd, Wartenberg, Andrea, Brien, Sarah, Lewith, George and Wegener, Tankred (2005) Devil's Claw (Harpagophytum procumbens): an anti-inflammatory herb with therapeutic potential Phytochemistry Reviews, 4, (1), 47 -53. (doi:10.1007/s11101-004-2374-8).

Record type: Article


Extracts of the secondary roots of the southern African plant, Devil’s Claw (Harpagophytum procumbens) provide a herbal drug with a variety of traditional indications. One area of its use that has become very popular in recent years is in the treatment of inflammatory disorders of the musculoskeletal system and of low back pain. There have been several clinical studies recently published that generally support its use in treating osteoarthritis although more studies are required in order to establish this drug as a definite therapeutic option. Here in this review, the pharmacological properties of Devil’s Claw are reviewed in detail and the clinical evidence is briefly summarised. There is good in vitro and in vivo pharmacological evidence of the anti-inflammatory and analgesic properties of this drug, although some negative findings have also been reported. Generally, the pharmacological properties of Devil’s Claw is supportive of its therapeutic potential, but more evidence from clinically relevant models, as well as at the cellular and molecular level, should be sought. Such studies may provide evidence in support of additional indications, both traditional and novel. The clinical data on Devil’s Claw is also very promising.

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Published date: 2005
Keywords: analgesic, anti-inflammatory, devil's claw, harpagophytum procumbens, osteoarthritis


Local EPrints ID: 24422
ISSN: 1568-7767
PURE UUID: 1783a93a-f7b2-4d1a-8dc1-61d069ae48fb

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Date deposited: 29 Mar 2006
Last modified: 17 Jul 2017 16:13

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Author: Gerard McGregor
Author: Bernd Fiebich
Author: Andrea Wartenberg
Author: Sarah Brien
Author: George Lewith
Author: Tankred Wegener

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