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Exposure to metal fume and infectious pneumonia

Exposure to metal fume and infectious pneumonia
Exposure to metal fume and infectious pneumonia
To test the hypothesis that inhalation of metal fume reversibly increases susceptibility to pneumonia, the authors conducted a case-control study. Men aged 20–64 years, admitted to 11 hospitals in West Midlands, England, with community-acquired pneumonia during 1996–1999 were interviewed about their lifetime occupational history, exposure to metal fume, and potential confounding factors. Similar information was collected from controls admitted to the same hospitals with nonrespiratory illness. For cases, exposures were timed relative to the onset of their illness (on average, 6 months before interview). Exposure histories for controls were censored 6 months before interview. Interviews were completed by 525 cases and 1,122 controls (response rates of 74% and 99%). Pneumonia was associated with reported occupational exposure to metal fume in the previous year (adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.1, 2.4) but not in earlier periods (OR = 1.1). The risk was highest for lobar pneumonia and recent exposure to ferrous fume (OR = 2.3, 95% CI: 1.2, 4.3). The association was not specific to any one microorganism. These findings support the hypothesis that ferrous and possibly other metal fumes reversibly predispose to infectious pneumonia. Research should now focus on the underlying mechanisms and prevention.
0002-9262
227-233
Palmer, K.T.
0cfe63f0-1d33-40ff-ae8c-6c33601df850
Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Ayres, J.G.
d3a3ba13-c8ee-45e8-878b-a8af69f718ac
Mann, J.
57d027bc-4bc3-412c-8e8d-8c584fc35062
Burge, P.S.
7dea81df-af8f-40a8-94e2-ce98d4a8697e
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Palmer, K.T.
0cfe63f0-1d33-40ff-ae8c-6c33601df850
Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Ayres, J.G.
d3a3ba13-c8ee-45e8-878b-a8af69f718ac
Mann, J.
57d027bc-4bc3-412c-8e8d-8c584fc35062
Burge, P.S.
7dea81df-af8f-40a8-94e2-ce98d4a8697e
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3

Palmer, K.T., Poole, J., Ayres, J.G., Mann, J., Burge, P.S. and Coggon, D. (2003) Exposure to metal fume and infectious pneumonia. American Journal of Epidemiology, 157 (3), 227-233. (doi:10.1093/aje/kwf188).

Record type: Article

Abstract

To test the hypothesis that inhalation of metal fume reversibly increases susceptibility to pneumonia, the authors conducted a case-control study. Men aged 20–64 years, admitted to 11 hospitals in West Midlands, England, with community-acquired pneumonia during 1996–1999 were interviewed about their lifetime occupational history, exposure to metal fume, and potential confounding factors. Similar information was collected from controls admitted to the same hospitals with nonrespiratory illness. For cases, exposures were timed relative to the onset of their illness (on average, 6 months before interview). Exposure histories for controls were censored 6 months before interview. Interviews were completed by 525 cases and 1,122 controls (response rates of 74% and 99%). Pneumonia was associated with reported occupational exposure to metal fume in the previous year (adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.1, 2.4) but not in earlier periods (OR = 1.1). The risk was highest for lobar pneumonia and recent exposure to ferrous fume (OR = 2.3, 95% CI: 1.2, 4.3). The association was not specific to any one microorganism. These findings support the hypothesis that ferrous and possibly other metal fumes reversibly predispose to infectious pneumonia. Research should now focus on the underlying mechanisms and prevention.

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More information

Published date: 1 February 2003

Identifiers

Local EPrints ID: 24447
URI: http://eprints.soton.ac.uk/id/eprint/24447
ISSN: 0002-9262
PURE UUID: d20ec07b-06f5-4b86-b5cf-07413deaf9ab
ORCID for D. Coggon: ORCID iD orcid.org/0000-0003-1930-3987

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 09 Jan 2022 02:51

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Contributors

Author: K.T. Palmer
Author: J. Poole
Author: J.G. Ayres
Author: J. Mann
Author: P.S. Burge
Author: D. Coggon ORCID iD

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