The University of Southampton
University of Southampton Institutional Repository

Simulation model of renal replacement therapy: Predicting future demand in England

Roderick, Paul, Davies, Ruth, Jones, Chris, Feest, Terry, Smith, Steve and Farrington, Ken (2004) Simulation model of renal replacement therapy: Predicting future demand in England Nephrology, Dialysis, Transplantation, 19, (3), pp. 692-701. (doi:10.1093/ndt/gfg591).

Record type: Article


Background. The demand for renal replacement therapy (RRT) in England has risen steadily, although from a lower base than many other developed countries. Predicting the future demand for RRT and the impact of factors such as the acceptance rate, transplant supply and patient survival, is required in order to inform the planning of such services.
Methods. A discrete event simulation model estimates the future demand for RRT in England in 2010 for a range of scenarios. The model uses current prevalence and current and projected future acceptance rates, survival rates and the transitions between modalities to predict future patient numbers. National population and mortality data, published literature and data from the UK Renal Registry and UK Transplant, are used to estimate unmet need for RRT, the impact of changing demography and incidence of Type 2 diabetes, patient haemodialysis (HD) survival and transplant supply.
Results. By 2010 the predicted prevalence will have increased from about 30 000 in 2000 to between 42 and 51 000 (900–1000 p.m.p.), an average annual growth of 4.5–6%. Changing transplant supply has a small effect on overall numbers but changes the proportion of patients with functioning graft by up to 8%. Even with an optimistic increase in transplant supply (11% p.a. for 5 years), numbers on HD will continue to rise substantially, especially in the elderly. The factors most influencing future patient numbers are the acceptance rate and dialysis survival.
Conclusion. This model predicts a substantial growth in the RRT population to 2010 to a rate approaching 1000 p.m.p., particularly in the elderly and those on HD, with a steady state not being reached for at least 25 years.

Full text not available from this repository.

More information

Published date: April 2004
Keywords: demand, renal replacement therapy, simulation model


Local EPrints ID: 24493
ISSN: 0931-0509
PURE UUID: cdad1301-3512-4eef-a866-68a0f2d8b52e
ORCID for Paul Roderick: ORCID iD

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 17 Jul 2017 16:13

Export record



Author: Paul Roderick ORCID iD
Author: Ruth Davies
Author: Chris Jones
Author: Terry Feest
Author: Steve Smith
Author: Ken Farrington

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.