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BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining

BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining
BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining
Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of susceptibility was also explored. Underground workers (drivers of diesel-powered excavators) at an oil shale mine in Estonia were compared with surface workers. Personal exposures to particle-associated 1-nitropyrene (NP) were some eight times higher underground than on the surface. Underground miners were also occupationally exposed to benzene and polycyclic aromatic hydrocarbons, as indicated by excretion of urinary metabolites of benzene and pyrene. In addition, increased O6-alkylguanine DNA adducts were detected in the white blood cells of underground workers, suggesting higher exposure to nitroso-compounds. However, no differences between underground and surface workers were observed in the levels of other bulky DNA adducts determined by 32P-postlabelling, or in DNA damage. The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results.
biological monitoring, benzene, polycyclic aromatic hydrocarbons, 1-nitropyrene, dna adducts, dna damage
0378-4274
305-317
Scheepers, P. T.
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Coggon, D.
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Knudsen, L. E.
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Anzion, R.
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Autrup, H.
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Bogovski, S.
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Bos, R. P.
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Dahmann, D.
854dd353-0bb9-404d-a0dd-582c1ed91b3c
Farmer, P.
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Martin, E. A.
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Micka, V.
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Muzyka, V.
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Neumann, H. G.
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Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Schmidt-Ott, A.
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Seiler, F.
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Volf, J.
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Zwirner-Baier, I.
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Scheepers, P. T.
fdb5854d-429e-48cf-8f3d-7ca28740097b
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Knudsen, L. E.
69ae01a3-8a05-4535-ac24-1e37ea70dd25
Anzion, R.
31de9767-225f-436b-ae04-48f98a57fec5
Autrup, H.
2432f5e4-5ca6-4102-8598-1128421c1205
Bogovski, S.
67e34c90-31ad-4587-bc89-914695f01c87
Bos, R. P.
170f44e6-a226-4940-88cf-56cc6cf23a0f
Dahmann, D.
854dd353-0bb9-404d-a0dd-582c1ed91b3c
Farmer, P.
9fdfefab-8b05-416b-8b20-3518f7f3dc62
Martin, E. A.
83782c8f-25d6-40b5-bdab-eb34acf3a05b
Micka, V.
e2e7d096-97bf-4757-abac-366c1852f68a
Muzyka, V.
a9f6316b-fd34-4112-9001-14c3019c7ed5
Neumann, H. G.
44d6baad-e015-4732-a333-1c51b7091fa8
Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Schmidt-Ott, A.
febfacef-62f6-4858-b8de-2244576f6f39
Seiler, F.
ab9a9e62-f8d6-4cc3-acd5-4e6daebdf34f
Volf, J.
cb4099a7-8906-4dc4-9fa2-c61f8200335d
Zwirner-Baier, I.
831db298-5397-4e7b-88b8-d178a84fd81c

Scheepers, P. T., Coggon, D., Knudsen, L. E., Anzion, R., Autrup, H., Bogovski, S., Bos, R. P., Dahmann, D., Farmer, P., Martin, E. A., Micka, V., Muzyka, V., Neumann, H. G., Poole, J., Schmidt-Ott, A., Seiler, F., Volf, J. and Zwirner-Baier, I. (2002) BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining. Toxicology Letters, 134 (1-3), 305-317. (doi:10.1016/S0378-4274(02)00195-9).

Record type: Article

Abstract

Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of susceptibility was also explored. Underground workers (drivers of diesel-powered excavators) at an oil shale mine in Estonia were compared with surface workers. Personal exposures to particle-associated 1-nitropyrene (NP) were some eight times higher underground than on the surface. Underground miners were also occupationally exposed to benzene and polycyclic aromatic hydrocarbons, as indicated by excretion of urinary metabolites of benzene and pyrene. In addition, increased O6-alkylguanine DNA adducts were detected in the white blood cells of underground workers, suggesting higher exposure to nitroso-compounds. However, no differences between underground and surface workers were observed in the levels of other bulky DNA adducts determined by 32P-postlabelling, or in DNA damage. The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results.

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More information

Published date: 2002
Keywords: biological monitoring, benzene, polycyclic aromatic hydrocarbons, 1-nitropyrene, dna adducts, dna damage

Identifiers

Local EPrints ID: 24498
URI: http://eprints.soton.ac.uk/id/eprint/24498
ISSN: 0378-4274
PURE UUID: 695abf98-8746-46e8-a579-2483b5249a18
ORCID for D. Coggon: ORCID iD orcid.org/0000-0003-1930-3987

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 09 Jan 2022 02:51

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Contributors

Author: P. T. Scheepers
Author: D. Coggon ORCID iD
Author: L. E. Knudsen
Author: R. Anzion
Author: H. Autrup
Author: S. Bogovski
Author: R. P. Bos
Author: D. Dahmann
Author: P. Farmer
Author: E. A. Martin
Author: V. Micka
Author: V. Muzyka
Author: H. G. Neumann
Author: J. Poole
Author: A. Schmidt-Ott
Author: F. Seiler
Author: J. Volf
Author: I. Zwirner-Baier

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