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The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice

The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice
The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice
It is unclear why some smokers develop chronic obstructive pulmonary disease (COPD) whilst the majority do not. Antioxidants found in food may protect against lung tissue injury, but previous epidemiological studies are inconsistent and do not focus on those most at risk of COPD, namely smokers. This case-controlled study measured the difference in dietary intake between smokers and ex-smokers with and without COPD.
Cases were patients >45 yrs of age with >10 pack-yrs of smoking, a forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) of ≤70% and a FEV1 of ≤80% of predicted. Controls were patients >45 yrs of age with >10 pack-yrs of smoking, a FEV1/FVC of >70% and a FEV1 >80% pred. Data were collected using validated questionnaires. Logistic regression analysis for an unmatched case-controlled study was performed.
After controlling for other independent predictors of COPD, those with vegetable intake of ≥1 portion·day–1 (93 g) were less likely to have COPD, as were those consuming ≥1.5 portions·day–1 of fruit. This was not due to an overall reduction in food/calorie intake caused by the disease because: 1) adjusting for body mass index did not alter the estimates; 2) the effect was specific to fruit and vegetables, i.e. not other food groups; and 3) the estimates from incident cases were similar.
In conclusion, fruit and vegetable consumption is inversely associated with chronic obstructive pulmonary disease and may explain why some smokers do not develop chronic obstructive pulmonary disease.
0903-1936
313-318
Watson, L.
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Margetts, B.
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Howarth, P.
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Dorward, M.
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Thompson, R.
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Little, P.
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Watson, L.
b19c88c5-88f3-44fe-935e-1cece1d079a2
Margetts, B.
d415f4a1-d572-4ebc-be25-f54886cb4788
Howarth, P.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Dorward, M.
ede98eab-1027-4a21-a38c-3bccb7c71e06
Thompson, R.
1a394a6d-b006-4aec-b9be-b3e6c16fdb7b
Little, P.
1bf2d1f7-200c-47a5-ab16-fe5a8756a777

Watson, L., Margetts, B., Howarth, P., Dorward, M., Thompson, R. and Little, P. (2002) The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice. European Respiratory Journal, 20 (2), 313-318.

Record type: Article

Abstract

It is unclear why some smokers develop chronic obstructive pulmonary disease (COPD) whilst the majority do not. Antioxidants found in food may protect against lung tissue injury, but previous epidemiological studies are inconsistent and do not focus on those most at risk of COPD, namely smokers. This case-controlled study measured the difference in dietary intake between smokers and ex-smokers with and without COPD.
Cases were patients >45 yrs of age with >10 pack-yrs of smoking, a forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) of ≤70% and a FEV1 of ≤80% of predicted. Controls were patients >45 yrs of age with >10 pack-yrs of smoking, a FEV1/FVC of >70% and a FEV1 >80% pred. Data were collected using validated questionnaires. Logistic regression analysis for an unmatched case-controlled study was performed.
After controlling for other independent predictors of COPD, those with vegetable intake of ≥1 portion·day–1 (93 g) were less likely to have COPD, as were those consuming ≥1.5 portions·day–1 of fruit. This was not due to an overall reduction in food/calorie intake caused by the disease because: 1) adjusting for body mass index did not alter the estimates; 2) the effect was specific to fruit and vegetables, i.e. not other food groups; and 3) the estimates from incident cases were similar.
In conclusion, fruit and vegetable consumption is inversely associated with chronic obstructive pulmonary disease and may explain why some smokers do not develop chronic obstructive pulmonary disease.

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Published date: August 2002

Identifiers

Local EPrints ID: 24550
URI: http://eprints.soton.ac.uk/id/eprint/24550
ISSN: 0903-1936
PURE UUID: 7c5c35c0-3947-45ba-a980-f0a986e7863f

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Date deposited: 31 Mar 2006
Last modified: 08 Jan 2022 18:52

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Contributors

Author: L. Watson
Author: B. Margetts
Author: P. Howarth
Author: M. Dorward
Author: R. Thompson
Author: P. Little

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