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Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism

Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism
Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism
The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasian patients with cutaneous malignant melanoma. The insertion allele was associated with deep invasive, and therefore poorer-prognosis, primary tumors [(34% of patients with vertical growth phase tumor were homozygous for the insertion allele compared with 17% of patients with horizontal growth phase tumor (P = 0.0333; odds ratio = 2.51)]. These data suggest that the invasiveness of cutaneous malignant melanoma is influenced by variation in the MMP-1 gene promoter that affects MMP-1 expression.
0008-5472
1296-1298
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Dhillon, Sahar
61831788-a120-426d-92d0-f15b8425bb57
Turner, Steven J.
bdd299f9-dba8-4c7c-adf1-c47ec98c6ae1
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Theaker, Jeffrey M.
a682fb66-7c35-4ae8-80bb-2425d8c43a41
Pickering, Ruth M.
4a828314-7ddf-4f96-abed-3407017d4c90
Day, Ian
dd32ab24-2ffc-435e-be2d-9fbb46055ae3
Howell, W. Martin
ecbb0dd6-f904-4da2-a05d-e542862531f8
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Dhillon, Sahar
61831788-a120-426d-92d0-f15b8425bb57
Turner, Steven J.
bdd299f9-dba8-4c7c-adf1-c47ec98c6ae1
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Theaker, Jeffrey M.
a682fb66-7c35-4ae8-80bb-2425d8c43a41
Pickering, Ruth M.
4a828314-7ddf-4f96-abed-3407017d4c90
Day, Ian
dd32ab24-2ffc-435e-be2d-9fbb46055ae3
Howell, W. Martin
ecbb0dd6-f904-4da2-a05d-e542862531f8

Ye, Shu, Dhillon, Sahar, Turner, Steven J., Bateman, Adrian C., Theaker, Jeffrey M., Pickering, Ruth M., Day, Ian and Howell, W. Martin (2001) Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism. Cancer Research, 61 (4), 1296-1298.

Record type: Article

Abstract

The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasian patients with cutaneous malignant melanoma. The insertion allele was associated with deep invasive, and therefore poorer-prognosis, primary tumors [(34% of patients with vertical growth phase tumor were homozygous for the insertion allele compared with 17% of patients with horizontal growth phase tumor (P = 0.0333; odds ratio = 2.51)]. These data suggest that the invasiveness of cutaneous malignant melanoma is influenced by variation in the MMP-1 gene promoter that affects MMP-1 expression.

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Published date: 2001

Identifiers

Local EPrints ID: 24564
URI: http://eprints.soton.ac.uk/id/eprint/24564
ISSN: 0008-5472
PURE UUID: f793f690-d1cd-41af-987e-7cd83257e418

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Date deposited: 31 Mar 2006
Last modified: 08 Jan 2022 09:52

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Contributors

Author: Shu Ye
Author: Sahar Dhillon
Author: Steven J. Turner
Author: Adrian C. Bateman
Author: Jeffrey M. Theaker
Author: Ian Day
Author: W. Martin Howell

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