The University of Southampton
University of Southampton Institutional Repository

Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus

Asumalahti, Kati, Veal, Colin, Laitinen, Tarja, Suomela, Sari, Allen, Michael, Elomaa, Outi, Moser, Michael, De Cid, Rafael, Ripatti, Samuli, Vorechovsky, Igor, Marcusson, Jan A., Nakagawa, Hidemi, Lazaro, Conxi, Estivill, Xavier, Capon, Francesca, Novelli, Giuseppe, Saarialho-Kere, Ulpu, Barker, Jonathan, Trembath, Richard and Kere, Juha (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus Human Molecular Genetics, 11, (5), pp. 589-597. (doi:10.1093/hmg/11.5.589).

Record type: Article


PSORS1, near HLA-C, is the major genetic determinant of psoriasis. We present genetic and structural evidence suggesting a major role for the HCR gene at the PSORS1 locus. Genotyping of 419 families from six populations revealed that coding single-nucleotide polymorphisms of HCR formed a conserved allele HCR*WWCC that associated highly significantly with psoriasis and with the HLA-Cw6 allele in all populations. Because of strong linkage disequilibrium between HLA-Cw6 and HCR*WWCC, the two genes could not be genetically distinguished by this sample size. However, the variant HCR allele was predicted to differ in secondary structure from the wild-type protein. HCR protein expression in lesional psoriatic skin differed considerably from that observed in normal skin. These results provide strong evidence for the HCR*WWCC allele as a major genetic determinant for psoriasis, probably by a mechanism impacting on keratinocyte proliferation.

Full text not available from this repository.

More information

Published date: 2002


Local EPrints ID: 24615
PURE UUID: f74411ca-8ede-4cc0-a637-bced6c560124

Catalogue record

Date deposited: 03 Apr 2006
Last modified: 17 Jul 2017 16:13

Export record



Author: Kati Asumalahti
Author: Colin Veal
Author: Tarja Laitinen
Author: Sari Suomela
Author: Michael Allen
Author: Outi Elomaa
Author: Michael Moser
Author: Rafael De Cid
Author: Samuli Ripatti
Author: Jan A. Marcusson
Author: Hidemi Nakagawa
Author: Conxi Lazaro
Author: Xavier Estivill
Author: Francesca Capon
Author: Giuseppe Novelli
Author: Ulpu Saarialho-Kere
Author: Jonathan Barker
Author: Richard Trembath
Author: Juha Kere

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.