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SF-1: a critical mediator of steroidogenesis

SF-1: a critical mediator of steroidogenesis
SF-1: a critical mediator of steroidogenesis
Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic–pituitary–steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner
5 - 7
Bakke, M.
d67bfad3-f4a5-4461-9e14-d10944046644
Zhao, L.
d8b9dbf3-307e-4925-8b4d-961bcb9859be
Hanley, N. A.
8badc148-de77-4f78-86b4-18bd64229b0d
Parker, K. L.
d89c238f-795c-482f-83e4-a9d7a6c38035
Bakke, M.
d67bfad3-f4a5-4461-9e14-d10944046644
Zhao, L.
d8b9dbf3-307e-4925-8b4d-961bcb9859be
Hanley, N. A.
8badc148-de77-4f78-86b4-18bd64229b0d
Parker, K. L.
d89c238f-795c-482f-83e4-a9d7a6c38035

Bakke, M., Zhao, L., Hanley, N. A. and Parker, K. L. (2001) SF-1: a critical mediator of steroidogenesis. Molecular and Cellular Endocrinology, 171 (1-2), 5 - 7. (doi:10.1016/S0303-7207(00)00384-1).

Record type: Article

Abstract

Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic–pituitary–steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner

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Published date: January 2001

Identifiers

Local EPrints ID: 24616
URI: http://eprints.soton.ac.uk/id/eprint/24616
PURE UUID: 85525392-615c-4aec-8676-0b9d8deab957

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Date deposited: 05 Apr 2006
Last modified: 15 Mar 2024 06:56

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Contributors

Author: M. Bakke
Author: L. Zhao
Author: N. A. Hanley
Author: K. L. Parker

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