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Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway

Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway
Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway
The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2. We have previously demonstrated that all three peptides are cardioprotective, and both the Akt and MAPK p42/44 pathways are essential for this effect. Here we tested the hypertrophic effects of these peptides. We examined the effects of the peptides on cell area, protein synthesis, and induction of the natriuretic peptides ANP and BNP. All three peptides were able to increase all the markers of hypertrophy examined, with SCP being the most potent of the three, followed by UCN and SRP last. In addition, we provide a mechanism of action for the three peptides and show that Akt phosphorylation is important for their hypertrophic action, whereas MAPK p42/44 is not involved in this effect.
urocortin, stresscopin, stresscopin related peptide, hypertrophy, akt, mapk, natriuretic peptides, cardiomyocytes
0006-291X
442-448
Chanalaris, Anastasios
72d46901-69ac-4892-b713-4963b1b5d14f
Lawrence, Kevin M.
ff8347b7-930c-4414-beab-65f6d6514b73
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Davidson, Sean
8068199b-1568-42ac-a783-b4b90b6b59d0
Jamshidi, Yalada
0d6463a0-aa4e-40d3-b88f-0eda59a98819
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Knight, Richard D.
ffc3d782-0502-426e-ac4b-bd9c56eaa5a1
Hsu, Sheau Y.
898c165d-e383-45c7-8676-4c98a0779f52
Hsueh, Aaron J.W.
87c35118-af62-45c8-a05b-f3b3f4dabd67
Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db
Chanalaris, Anastasios
72d46901-69ac-4892-b713-4963b1b5d14f
Lawrence, Kevin M.
ff8347b7-930c-4414-beab-65f6d6514b73
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Davidson, Sean
8068199b-1568-42ac-a783-b4b90b6b59d0
Jamshidi, Yalada
0d6463a0-aa4e-40d3-b88f-0eda59a98819
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Knight, Richard D.
ffc3d782-0502-426e-ac4b-bd9c56eaa5a1
Hsu, Sheau Y.
898c165d-e383-45c7-8676-4c98a0779f52
Hsueh, Aaron J.W.
87c35118-af62-45c8-a05b-f3b3f4dabd67
Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db

Chanalaris, Anastasios, Lawrence, Kevin M., Townsend, Paul A., Davidson, Sean, Jamshidi, Yalada, Stephanou, Anastasis, Knight, Richard D., Hsu, Sheau Y., Hsueh, Aaron J.W. and Latchman, David S. (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochemical and Biophysical Research Communications, 328 (2), 442-448. (doi:10.1016/j.bbrc.2005.01.001).

Record type: Article

Abstract

The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2. We have previously demonstrated that all three peptides are cardioprotective, and both the Akt and MAPK p42/44 pathways are essential for this effect. Here we tested the hypertrophic effects of these peptides. We examined the effects of the peptides on cell area, protein synthesis, and induction of the natriuretic peptides ANP and BNP. All three peptides were able to increase all the markers of hypertrophy examined, with SCP being the most potent of the three, followed by UCN and SRP last. In addition, we provide a mechanism of action for the three peptides and show that Akt phosphorylation is important for their hypertrophic action, whereas MAPK p42/44 is not involved in this effect.

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More information

Published date: 2005
Keywords: urocortin, stresscopin, stresscopin related peptide, hypertrophy, akt, mapk, natriuretic peptides, cardiomyocytes

Identifiers

Local EPrints ID: 24648
URI: https://eprints.soton.ac.uk/id/eprint/24648
ISSN: 0006-291X
PURE UUID: 45b12ad4-6f0e-4e6d-91df-619c3041517d

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Date deposited: 03 Apr 2006
Last modified: 17 Jul 2017 16:13

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Contributors

Author: Anastasios Chanalaris
Author: Kevin M. Lawrence
Author: Paul A. Townsend
Author: Sean Davidson
Author: Yalada Jamshidi
Author: Anastasis Stephanou
Author: Richard D. Knight
Author: Sheau Y. Hsu
Author: Aaron J.W. Hsueh
Author: David S. Latchman

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