Cytogenetics of chronic myeloid leukaemia
Cytogenetics of chronic myeloid leukaemia
The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10–30% of patients at diagnosis and may confer a worse prognosis. Additional cytogenetic changes can occur in the few months before or during disease progression and are often specific for blast morphology; however, the molecular basis of the most common additional cytogenetic abnormalities is largely unknown. Cytogenetics is important for monitoring patient response to treatment but is increasingly being replaced by the more sensitive and less invasive techniques of RT-PCR and FISH.
cml, bcr, abl, cytogenetics
553-571
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Huntly, Brian. J. P.
d436e83e-188c-4b36-a36b-b38b16eb3c10
Cross, Nicholas. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4
2001
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Huntly, Brian. J. P.
d436e83e-188c-4b36-a36b-b38b16eb3c10
Cross, Nicholas. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Chase, Andrew, Huntly, Brian. J. P. and Cross, Nicholas. C. P.
(2001)
Cytogenetics of chronic myeloid leukaemia.
Best Practice and Research Clinical Haematology, 14 (3), .
(doi:10.1053/beha.2001.0154).
Abstract
The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10–30% of patients at diagnosis and may confer a worse prognosis. Additional cytogenetic changes can occur in the few months before or during disease progression and are often specific for blast morphology; however, the molecular basis of the most common additional cytogenetic abnormalities is largely unknown. Cytogenetics is important for monitoring patient response to treatment but is increasingly being replaced by the more sensitive and less invasive techniques of RT-PCR and FISH.
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Published date: 2001
Keywords:
cml, bcr, abl, cytogenetics
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Local EPrints ID: 24649
URI: http://eprints.soton.ac.uk/id/eprint/24649
ISSN: 1521-6926
PURE UUID: fb4c8f68-cbdf-4356-bd6b-aeb2511ca510
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Date deposited: 04 Apr 2006
Last modified: 16 Mar 2024 03:23
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Author:
Brian. J. P. Huntly
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