The University of Southampton
University of Southampton Institutional Repository

Cytogenetics of chronic myeloid leukaemia

Cytogenetics of chronic myeloid leukaemia
Cytogenetics of chronic myeloid leukaemia
The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10–30% of patients at diagnosis and may confer a worse prognosis. Additional cytogenetic changes can occur in the few months before or during disease progression and are often specific for blast morphology; however, the molecular basis of the most common additional cytogenetic abnormalities is largely unknown. Cytogenetics is important for monitoring patient response to treatment but is increasingly being replaced by the more sensitive and less invasive techniques of RT-PCR and FISH.
cml, bcr, abl, cytogenetics
1521-6926
553-571
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Huntly, Brian. J. P.
d436e83e-188c-4b36-a36b-b38b16eb3c10
Cross, Nicholas. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Huntly, Brian. J. P.
d436e83e-188c-4b36-a36b-b38b16eb3c10
Cross, Nicholas. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4

Chase, Andrew, Huntly, Brian. J. P. and Cross, Nicholas. C. P. (2001) Cytogenetics of chronic myeloid leukaemia. Best Practice & Research: Clinical Haematology, 14 (3), 553-571. (doi:10.1053/beha.2001.0154).

Record type: Article

Abstract

The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10–30% of patients at diagnosis and may confer a worse prognosis. Additional cytogenetic changes can occur in the few months before or during disease progression and are often specific for blast morphology; however, the molecular basis of the most common additional cytogenetic abnormalities is largely unknown. Cytogenetics is important for monitoring patient response to treatment but is increasingly being replaced by the more sensitive and less invasive techniques of RT-PCR and FISH.

Full text not available from this repository.

More information

Published date: 2001
Keywords: cml, bcr, abl, cytogenetics

Identifiers

Local EPrints ID: 24649
URI: https://eprints.soton.ac.uk/id/eprint/24649
ISSN: 1521-6926
PURE UUID: fb4c8f68-cbdf-4356-bd6b-aeb2511ca510
ORCID for Nicholas. C. P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 04 Apr 2006
Last modified: 06 Oct 2018 00:36

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×