Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling
Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling
Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction. We propose that multiple steps of gene induction recruit a wider spectrum of MMPs, which may ultimately lead to a transition from matrix turnover to matrix destruction. Studying the detailed mechanisms involved may suggest possibilities for intervening selectively against pathological MMP induction.
metalloproteinases, endothelial cells, macrophages, vascular smooth muscle cells, genes, transcription, transcription factors, extracellular matrix, proteolysis
329-343
Chase, Alex J.
a40a09c2-3073-4655-ba0b-a802e34914b5
Newby, Andrew C.
dbe300f7-7615-4196-a3b4-ee35ab5df9ec
2003
Chase, Alex J.
a40a09c2-3073-4655-ba0b-a802e34914b5
Newby, Andrew C.
dbe300f7-7615-4196-a3b4-ee35ab5df9ec
Chase, Alex J. and Newby, Andrew C.
(2003)
Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling.
Journal of Vascular Research, 40 (4), .
(doi:10.1159/000072697).
Abstract
Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction. We propose that multiple steps of gene induction recruit a wider spectrum of MMPs, which may ultimately lead to a transition from matrix turnover to matrix destruction. Studying the detailed mechanisms involved may suggest possibilities for intervening selectively against pathological MMP induction.
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Published date: 2003
Keywords:
metalloproteinases, endothelial cells, macrophages, vascular smooth muscle cells, genes, transcription, transcription factors, extracellular matrix, proteolysis
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Local EPrints ID: 24650
URI: http://eprints.soton.ac.uk/id/eprint/24650
ISSN: 1018-1172
PURE UUID: f238dde8-d5c6-43bc-b088-753f7e07da2b
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Date deposited: 04 Apr 2006
Last modified: 15 Mar 2024 06:57
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Author:
Andrew C. Newby
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