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Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling

Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling
Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling
Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction. We propose that multiple steps of gene induction recruit a wider spectrum of MMPs, which may ultimately lead to a transition from matrix turnover to matrix destruction. Studying the detailed mechanisms involved may suggest possibilities for intervening selectively against pathological MMP induction.
metalloproteinases, endothelial cells, macrophages, vascular smooth muscle cells, genes, transcription, transcription factors, extracellular matrix, proteolysis
1018-1172
329-343
Chase, Alex J.
a40a09c2-3073-4655-ba0b-a802e34914b5
Newby, Andrew C.
dbe300f7-7615-4196-a3b4-ee35ab5df9ec
Chase, Alex J.
a40a09c2-3073-4655-ba0b-a802e34914b5
Newby, Andrew C.
dbe300f7-7615-4196-a3b4-ee35ab5df9ec

Chase, Alex J. and Newby, Andrew C. (2003) Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling. Journal of Vascular Research, 40 (4), 329-343. (doi:10.1159/000072697).

Record type: Article

Abstract

Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction. We propose that multiple steps of gene induction recruit a wider spectrum of MMPs, which may ultimately lead to a transition from matrix turnover to matrix destruction. Studying the detailed mechanisms involved may suggest possibilities for intervening selectively against pathological MMP induction.

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More information

Published date: 2003
Keywords: metalloproteinases, endothelial cells, macrophages, vascular smooth muscle cells, genes, transcription, transcription factors, extracellular matrix, proteolysis

Identifiers

Local EPrints ID: 24650
URI: http://eprints.soton.ac.uk/id/eprint/24650
ISSN: 1018-1172
PURE UUID: f238dde8-d5c6-43bc-b088-753f7e07da2b
ORCID for Alex J. Chase: ORCID iD orcid.org/0000-0001-6617-9953

Catalogue record

Date deposited: 04 Apr 2006
Last modified: 27 Apr 2022 11:07

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Contributors

Author: Alex J. Chase ORCID iD
Author: Andrew C. Newby

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