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Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women’s Heart and Health Study

Record type: Article

AIMS/HYPOTHESIS: It has been suggested that the gene encoding lymphotoxin-alpha (LTA) is associated with insulin resistance, and genetic association studies in the LTA region offer some support for this. However, LTA is in linkage disequilibrium with both the HLA gene cluster and the gene encoding TNF-alpha, making inferences about causality difficult. In this study, we used the galectin 2 (LGALS2) genotype, which affects LTA secretion but is located on another chromosome than the HLA gene cluster or TNF, to examine the relationship between the LTA pathway and traits of the metabolic syndrome.
SUBJECTS: A cross-sectional genetic association study was carried out in 3,272 British women of European origin who were aged 60 to 79 years and were randomly selected from the community.
RESULTS: Fasting plasma glucose and serum insulin were statistically significantly associated with LGALS2 rs7291467, with this association being independent of BMI and WHR. The mean difference in fasting insulin per minor allele was -4% (p=0.01 for trend by allele) and the mean per minor allele difference in fasting glucose was -2% (p=0.02 for trend by allele). When women with known diabetes were excluded from the analyses the findings did not differ from those for the whole cohort.
CONCLUSIONS/INTERPRETATION: Our findings for the physically unlinked LGALS2, invite further study of LGALS2 specifically and the LTA pathway generally for their influence on glucose-insulin regulation.

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Citation

Christensen, M.B., Lawlor, D.A., Gaunt, T.R., Howell, M.W., Davey Smith, G., Ebrahim, S. and Day, I.N.M. (2006) Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women’s Heart and Health Study Diabetologia, 49, (4), pp. 673-677. (doi:10.1007/s00125-006-0145-3).

More information

Published date: 2006
Keywords: secretion, linkage disequilibrium, human, cohort, genetics, causality, genotype, fasting, syndrome, insulin, health, affect, insulin resistance, glucose, diabetes, plasma, aged, heart
Organisations: Human Genetics

Identifiers

Local EPrints ID: 24653
URI: http://eprints.soton.ac.uk/id/eprint/24653
ISSN: 0012-186X
PURE UUID: f3d36ab3-4d47-4019-bf88-8044d704ab59

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 17 Jul 2017 16:13

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Contributors

Author: M.B. Christensen
Author: D.A. Lawlor
Author: T.R. Gaunt
Author: M.W. Howell
Author: G. Davey Smith
Author: S. Ebrahim
Author: I.N.M. Day

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