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Mapping genes for common diseases: the case for genetic (LD) maps

Mapping genes for common diseases: the case for genetic (LD) maps
Mapping genes for common diseases: the case for genetic (LD) maps
We examine the current effort to develop a haplotype map of the human genome and suggest an alternative approach which represents linkage disequilibrium patterns in the form of a metric LD map. LD maps have some of the useful properties of genetic linkage maps but have a much higher resolution which is optimal for SNP-based association mapping of common diseases. The studies that have been undertaken to date suggest that LD and recombination maps show some close similarities because of abundant, narrow, recombination hot spots. These hot spots are co-localised in all populations but, unlike linkage maps, LD maps differ in scale for different populations because of differences in population history. The prospects for developing optimized panels of SNPs and the use of linkage disequilibrium maps in disease gene localisation are assessed in the light of recent evidence.
linkage disequilibrium map, linkage map, haplotype block, hapmap project, recombination hot spot
0001-5652
2-9
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Lau, Winston
2ae746d0-c61c-449f-b447-a95e9f3f7503
De La Vega, Francisco
c7b65bbb-38b8-46c7-98d6-69529e277e76
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Lau, Winston
2ae746d0-c61c-449f-b447-a95e9f3f7503
De La Vega, Francisco
c7b65bbb-38b8-46c7-98d6-69529e277e76

Collins, Andrew, Lau, Winston and De La Vega, Francisco (2004) Mapping genes for common diseases: the case for genetic (LD) maps. Human Heredity, 58 (1), 2-9. (doi:10.1159/000081451).

Record type: Article

Abstract

We examine the current effort to develop a haplotype map of the human genome and suggest an alternative approach which represents linkage disequilibrium patterns in the form of a metric LD map. LD maps have some of the useful properties of genetic linkage maps but have a much higher resolution which is optimal for SNP-based association mapping of common diseases. The studies that have been undertaken to date suggest that LD and recombination maps show some close similarities because of abundant, narrow, recombination hot spots. These hot spots are co-localised in all populations but, unlike linkage maps, LD maps differ in scale for different populations because of differences in population history. The prospects for developing optimized panels of SNPs and the use of linkage disequilibrium maps in disease gene localisation are assessed in the light of recent evidence.

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More information

Published date: December 2004
Keywords: linkage disequilibrium map, linkage map, haplotype block, hapmap project, recombination hot spot

Identifiers

Local EPrints ID: 24661
URI: https://eprints.soton.ac.uk/id/eprint/24661
ISSN: 0001-5652
PURE UUID: 0dc74c77-6f48-4335-86d2-b5c3c4868e38
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

Catalogue record

Date deposited: 04 Apr 2006
Last modified: 06 Jun 2018 13:11

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