A perspective on inversin
A perspective on inversin
Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.
inversin, situs inversus, primary cilia, nephronopthisis
119-124
Eley, Lorraine
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Turnpenny, Lee
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Yates, Laura M.
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Craighead, A. Scott
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Morgan, David
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Whistler, Catherine
ed101f5f-808f-46b8-a43a-79bbddbdc7aa
Goodship, Judith A.
033ac310-b737-467f-a5e0-8c2c4bbe8551
Strachan, Tom
9ab590c0-9f84-43f4-8bf3-0946c7925594
2004
Eley, Lorraine
221d3abc-efd1-4e82-8537-b20eb272558b
Turnpenny, Lee
31a2fb0f-b76a-490a-845d-f9d9a1501d3d
Yates, Laura M.
d5cf967d-f416-487c-a566-c132f9751a02
Craighead, A. Scott
18fc90ad-c02a-49d0-b25f-3908b4a0dc73
Morgan, David
7eaba985-9217-4b5a-9d33-0f2caf51b4e1
Whistler, Catherine
ed101f5f-808f-46b8-a43a-79bbddbdc7aa
Goodship, Judith A.
033ac310-b737-467f-a5e0-8c2c4bbe8551
Strachan, Tom
9ab590c0-9f84-43f4-8bf3-0946c7925594
Eley, Lorraine, Turnpenny, Lee, Yates, Laura M., Craighead, A. Scott, Morgan, David, Whistler, Catherine, Goodship, Judith A. and Strachan, Tom
(2004)
A perspective on inversin.
Cell Biology International, 28 (2), .
(doi:10.1016/j.cellbi.2003.11.009).
Abstract
Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.
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Published date: 2004
Additional Information:
Primary Cilia
Keywords:
inversin, situs inversus, primary cilia, nephronopthisis
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Local EPrints ID: 24691
URI: http://eprints.soton.ac.uk/id/eprint/24691
ISSN: 1065-6995
PURE UUID: 1a344c27-b76a-4664-a120-314e1c51b8a9
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Date deposited: 03 Apr 2006
Last modified: 15 Mar 2024 06:57
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Author:
Lorraine Eley
Author:
Lee Turnpenny
Author:
Laura M. Yates
Author:
A. Scott Craighead
Author:
David Morgan
Author:
Catherine Whistler
Author:
Judith A. Goodship
Author:
Tom Strachan
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