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A perspective on inversin

Eley, Lorraine, Turnpenny, Lee, Yates, Laura M., Craighead, A. Scott, Morgan, David, Whistler, Catherine, Goodship, Judith A. and Strachan, Tom (2004) A perspective on inversin Cell Biology International, 28, (2), pp. 119-124. (doi:10.1016/j.cellbi.2003.11.009).

Record type: Article

Abstract

Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.

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More information

Published date: 2004
Additional Information: Primary Cilia
Keywords: inversin, situs inversus, primary cilia, nephronopthisis

Identifiers

Local EPrints ID: 24691
URI: http://eprints.soton.ac.uk/id/eprint/24691
ISSN: 1065-6995
PURE UUID: 1a344c27-b76a-4664-a120-314e1c51b8a9

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Date deposited: 03 Apr 2006
Last modified: 17 Jul 2017 16:12

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Contributors

Author: Lorraine Eley
Author: Lee Turnpenny
Author: Laura M. Yates
Author: A. Scott Craighead
Author: David Morgan
Author: Catherine Whistler
Author: Judith A. Goodship
Author: Tom Strachan

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