A perspective on inversin

Eley, Lorraine, Turnpenny, Lee, Yates, Laura M., Craighead, A. Scott, Morgan, David, Whistler, Catherine, Goodship, Judith A. and Strachan, Tom (2004) A perspective on inversin Cell Biology International, 28, (2), pp. 119-124. (doi:10.1016/j.cellbi.2003.11.009).


Full text not available from this repository.


Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.cellbi.2003.11.009
Additional Information: Primary Cilia
ISSNs: 1065-6995 (print)
Related URLs:
Keywords: inversin, situs inversus, primary cilia, nephronopthisis

ePrint ID: 24691
Date :
Date Event
Date Deposited: 03 Apr 2006
Last Modified: 16 Apr 2017 22:39
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/24691

Actions (login required)

View Item View Item