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Human evidence that the Cystatin C Gene is implicated in focal progression of Coronary Artery Disease

Eriksson, Per, Deguchi, Hiroyuki, Samnegard, Ann, Lundman, Pia, Boquist, Susanna, Tornvall, Per, Ericsson, Carl-Goran, Bergstrand, Lott, Hansson, Lars-Olof, Ye, Shu and Hamsten, Anders (2004) Human evidence that the Cystatin C Gene is implicated in focal progression of Coronary Artery Disease Arteriosclerosis, Thrombosis, and Vascular Biology, 24, (3), pp. 551-557. (doi:10.1161/01.ATV.0000117180.57731.36).

Record type: Article

Abstract

Objective— Overexpression of elastolytic cysteine and aspartic proteases, known as cathepsins, is implicated in atherogenesis. The potential significance of imbalance in expression between cathepsins and their inhibitor cystatin C in cardiovascular disease has been highlighted by the demonstration of cystatin C deficiency in human atherosclerosis and abdominal aortic aneurysms.
Methods and Results— We identified and characterized physiologically relevant polymorphisms in the promoter region of the cystatin C gene that influence cystatin C production and used these polymorphisms as a tool to examine the significance of cystatin C in coronary atherosclerosis in vivo in humans. Seven polymorphisms, all in strong-linkage disequilibrium, were identified in the cystatin C gene, of which 2 promoter polymorphisms (-82G/C and -78T/G) were functional in vitro in electromobility shift and transient transfection assays. Genotyping of 1105 individuals (237 survivors of a first myocardial infarction before age 60 and 2 independent groups comprising a total of 868 healthy individuals) revealed that the plasma cystatin C concentration was significantly lower in carriers of the mutant haplotype. Furthermore, the mutant haplotype was associated with a higher average number of stenoses per coronary artery segment in unselected postinfarction patients (N=237) undergoing routine coronary angiography.
Conclusions— These results provide human evidence for an important role of cystatin C in coronary artery disease.

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More information

Published date: 2004
Keywords: cystatin c, genetics, coronary artery disease, promoter, remodeling

Identifiers

Local EPrints ID: 24695
URI: http://eprints.soton.ac.uk/id/eprint/24695
ISSN: 1079-5642
PURE UUID: 03dc02be-b509-485a-9031-f64499cd1a77

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Date deposited: 04 Apr 2006
Last modified: 17 Jul 2017 16:12

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Contributors

Author: Per Eriksson
Author: Hiroyuki Deguchi
Author: Ann Samnegard
Author: Pia Lundman
Author: Susanna Boquist
Author: Per Tornvall
Author: Carl-Goran Ericsson
Author: Lott Bergstrand
Author: Lars-Olof Hansson
Author: Shu Ye
Author: Anders Hamsten

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