HLA and eye disease: a synopsis
HLA and eye disease: a synopsis
Human leukocyte antigen (HLA) gene products have been implicated in the pathogenesis of an increasing number of eye diseases, mainly inflammatory in nature. This perspective reviews the current hypotheses for why HLA polymorphisms are associated with specific eye diseases. Statistical problems in studies involving HLA associations are discussed, and possible solutions outlined. The relevance of HLA testing in routine ophthalmic practice, its practical and cost implications is also assessed.
333-342
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
2005
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Abstract
Human leukocyte antigen (HLA) gene products have been implicated in the pathogenesis of an increasing number of eye diseases, mainly inflammatory in nature. This perspective reviews the current hypotheses for why HLA polymorphisms are associated with specific eye diseases. Statistical problems in studies involving HLA associations are discussed, and possible solutions outlined. The relevance of HLA testing in routine ophthalmic practice, its practical and cost implications is also assessed.
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Published date: 2005
Organisations:
Faculty of Medicine
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Local EPrints ID: 24720
URI: http://eprints.soton.ac.uk/id/eprint/24720
ISSN: 1744-3121
PURE UUID: 80d06407-b8be-4206-944b-f3eead2c4af8
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Date deposited: 03 Apr 2006
Last modified: 16 Mar 2024 03:31
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Author:
S.V. Goverdhan
Author:
W.M. Howell
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