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HLA and eye disease: a synopsis

HLA and eye disease: a synopsis
HLA and eye disease: a synopsis
Human leukocyte antigen (HLA) gene products have been implicated in the pathogenesis of an increasing number of eye diseases, mainly inflammatory in nature. This perspective reviews the current hypotheses for why HLA polymorphisms are associated with specific eye diseases. Statistical problems in studies involving HLA associations are discussed, and possible solutions outlined. The relevance of HLA testing in routine ophthalmic practice, its practical and cost implications is also assessed.
1744-3121
333-342
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454

Goverdhan, S.V., Lotery, A.J. and Howell, W.M. (2005) HLA and eye disease: a synopsis. International Journal of Immunogenetics, 32 (6), 333-342. (doi:10.1111/j.1744-313X.2005.00548.x).

Record type: Article

Abstract

Human leukocyte antigen (HLA) gene products have been implicated in the pathogenesis of an increasing number of eye diseases, mainly inflammatory in nature. This perspective reviews the current hypotheses for why HLA polymorphisms are associated with specific eye diseases. Statistical problems in studies involving HLA associations are discussed, and possible solutions outlined. The relevance of HLA testing in routine ophthalmic practice, its practical and cost implications is also assessed.

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Published date: 2005
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 24720
URI: http://eprints.soton.ac.uk/id/eprint/24720
ISSN: 1744-3121
PURE UUID: 80d06407-b8be-4206-944b-f3eead2c4af8
ORCID for A.J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 03 Apr 2006
Last modified: 20 Jul 2019 01:01

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Contributors

Author: S.V. Goverdhan
Author: A.J. Lotery ORCID iD
Author: W.M. Howell

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