NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia
NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia
The molecular basis for disease progression in chronic myeloid leukaemia (CML) is poorly understood, but is believed to be a consequence of additional acquired genetic lesions. We describe here a case of CML who presented de novo in transformation with a t(9;11)(p21;p15) and NUP98-LEDGF fusion in addition to the t(9;22). The t(9;11) was present in only 2/45 (4%) of bone marrow metaphases, but 17/20 (85%) of metaphases from peripheral blood, suggesting an extramedullary or focal origin. This is the first description of NUP98-LEDGF in CML and strengthens the association between disease progression in and NUP98 abnormalities.
cml, blask crisis, nup98, ledgf
1469-1472
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31
Koduru, Prasad
61113b0b-28e1-4ba3-8140-bf28994f116e
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Allen, Steven L.
1e7de2d2-460c-42e6-b263-2989c34243be
2005
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31
Koduru, Prasad
61113b0b-28e1-4ba3-8140-bf28994f116e
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Allen, Steven L.
1e7de2d2-460c-42e6-b263-2989c34243be
Grand, Francis H., Koduru, Prasad, Cross, Nicholas C.P. and Allen, Steven L.
(2005)
NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia.
Leukemia Research, 29 (12), .
(doi:10.1016/j.leukres.2005.05.002).
Abstract
The molecular basis for disease progression in chronic myeloid leukaemia (CML) is poorly understood, but is believed to be a consequence of additional acquired genetic lesions. We describe here a case of CML who presented de novo in transformation with a t(9;11)(p21;p15) and NUP98-LEDGF fusion in addition to the t(9;22). The t(9;11) was present in only 2/45 (4%) of bone marrow metaphases, but 17/20 (85%) of metaphases from peripheral blood, suggesting an extramedullary or focal origin. This is the first description of NUP98-LEDGF in CML and strengthens the association between disease progression in and NUP98 abnormalities.
This record has no associated files available for download.
More information
Published date: 2005
Keywords:
cml, blask crisis, nup98, ledgf
Identifiers
Local EPrints ID: 24727
URI: http://eprints.soton.ac.uk/id/eprint/24727
ISSN: 0145-2126
PURE UUID: 0d081a49-6bcd-47fd-bee8-e2b6c259a512
Catalogue record
Date deposited: 03 Apr 2006
Last modified: 16 Mar 2024 03:23
Export record
Altmetrics
Contributors
Author:
Francis H. Grand
Author:
Prasad Koduru
Author:
Steven L. Allen
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
