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Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families

Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families
Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families
Atopy and asthma are complex genetic diseases resulting from the interactions of a number of genetic and environmental factors. We had previously reported allelic association between the IL9 marker on chromosome 5q31-33 and atopy. In order to further investigate the role of susceptibility genes on 5q31-33 in the development of atopy and asthma we have studied 240 UK families comprising 131 families selected at random, 60 multiplex families with affected sib pairs, and 49 single proband nuclear families. Polymorphic markers on 5q31-33 were genotyped and both single and multipoint linkage analysis was undertaken using the BETA program. We have used both affection status and quantitative scores for atopy and asthma for phenotypic variables, combining data into scores for asthma and atopy. The strongest suggestion of linkage using multipoint analysis was centred around D5S410 with a maximum Lod of 1.946 at location 171.3 cM and a standard error of 3.3 for the asthma quantitative score. There was no evidence of linkage with atopy, the atopy quantitative score or total serum IgE.
asthma, atopy, IgE, linkage, chromosome 5q
1466-4879
20-24
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Lonjou, C.
81c7b685-b148-4d1e-a8e7-cbc75e8bc16a
Beghe, B.
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Peng, Q.
ca0f24d6-e072-44d9-89ff-6f6d80b0c91e
Gaunt, T.R.
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Gomes, I.
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Hall, I.P.
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Dewar, J.C.
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Wilkinson, J.
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Thomas, N S
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Holgate, S.T.
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Morton, N.E.
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Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Lonjou, C.
81c7b685-b148-4d1e-a8e7-cbc75e8bc16a
Beghe, B.
d4335e8e-fd57-41e3-9d71-69c0886bf145
Peng, Q.
ca0f24d6-e072-44d9-89ff-6f6d80b0c91e
Gaunt, T.R.
0867a942-06a8-4e40-9c97-c47124d474e9
Gomes, I.
36879969-b285-44d2-9140-8ef7c97866f1
Hall, I.P.
9278631f-4d1f-4187-9891-d8488e01b42d
Dewar, J.C.
2434c834-1090-4a9f-b6b7-3c35a072246a
Wilkinson, J.
fb7e8304-8448-49f0-9b4d-e52cdb9027fd
Thomas, N S
bfe39cd3-60b9-4733-8921-db53f7851e4c
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Holloway, J.W., Lonjou, C., Beghe, B., Peng, Q., Gaunt, T.R., Gomes, I., Hall, I.P., Dewar, J.C., Wilkinson, J., Thomas, N S, Holgate, S.T. and Morton, N.E. (2001) Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families. Genes and Immunity, 2 (1), 20-24. (doi:10.1038/sj.gene.6363723).

Record type: Article

Abstract

Atopy and asthma are complex genetic diseases resulting from the interactions of a number of genetic and environmental factors. We had previously reported allelic association between the IL9 marker on chromosome 5q31-33 and atopy. In order to further investigate the role of susceptibility genes on 5q31-33 in the development of atopy and asthma we have studied 240 UK families comprising 131 families selected at random, 60 multiplex families with affected sib pairs, and 49 single proband nuclear families. Polymorphic markers on 5q31-33 were genotyped and both single and multipoint linkage analysis was undertaken using the BETA program. We have used both affection status and quantitative scores for atopy and asthma for phenotypic variables, combining data into scores for asthma and atopy. The strongest suggestion of linkage using multipoint analysis was centred around D5S410 with a maximum Lod of 1.946 at location 171.3 cM and a standard error of 3.3 for the asthma quantitative score. There was no evidence of linkage with atopy, the atopy quantitative score or total serum IgE.

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Published date: 2001
Keywords: asthma, atopy, IgE, linkage, chromosome 5q
Organisations: Human Genetics, Faculty of Medicine, Infection Inflammation & Immunity, Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 24757
URI: https://eprints.soton.ac.uk/id/eprint/24757
ISSN: 1466-4879
PURE UUID: 53397243-cfcd-4b5c-9008-f0cf5038e673
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 03 Apr 2006
Last modified: 06 Jun 2018 12:59

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Contributors

Author: J.W. Holloway ORCID iD
Author: C. Lonjou
Author: B. Beghe
Author: Q. Peng
Author: T.R. Gaunt
Author: I. Gomes
Author: I.P. Hall
Author: J.C. Dewar
Author: J. Wilkinson
Author: N S Thomas
Author: S.T. Holgate
Author: N.E. Morton

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