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Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China)

Jia, Wei-Hua, Collins, Andrew, Zeng, Yi-Xin, Feng, Bing-Jian, Yu, Xing Juan, Huang, Li-Xi, Feng, Qi-Sheng, Huang, Ping, Yao, Ming Hong and Shugart, Yin Yao (2005) Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China) European Journal of Human Genetics, 13, (2), pp. 248-252. (doi:10.1038/sj.ejhg.5201305).

Record type: Article

Abstract

The striking geographical and ethnic distribution of nasopharyngeal carcinoma (NPC) suggests the involvement of genetic and environmental factors in NPC development. The purpose of this study is to investigate the fit of single gene, polygenic and multifactorial models to the observed pattern of transmission of NPC in a hospital-based family history study conducted by the Cancer Center of Sun Yat-Sen University (CCSYU) in Guangzhou, China. Complex segregation analysis of a total of 1903 Cantonese pedigrees ascertained at CCSYU was conducted using a unified mixed model after the pedigrees were partitioned into 3737 nuclear families. The mixed model assumes that a phenotype is influenced by the additive and independent effect of a major gene, together with multifactorial components (genetic and environmental) and a random environmental effect. The current results do not provide evidence for a major gene and the observed data are best explained by a multifactorial mode of inheritance for NPC.

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Published date: February 2005
Keywords: nasopharyngeal carcinoma (npc), complex segregation analysis, mode of inheritance, multifactorial model

Identifiers

Local EPrints ID: 24782
URI: http://eprints.soton.ac.uk/id/eprint/24782
ISSN: 1018-4813
PURE UUID: 0991c621-87ee-4a97-aaba-55c84f765cd7
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

Catalogue record

Date deposited: 03 Apr 2006
Last modified: 17 Jul 2017 16:12

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Contributors

Author: Wei-Hua Jia
Author: Andrew Collins ORCID iD
Author: Yi-Xin Zeng
Author: Bing-Jian Feng
Author: Xing Juan Yu
Author: Li-Xi Huang
Author: Qi-Sheng Feng
Author: Ping Huang
Author: Ming Hong Yao
Author: Yin Yao Shugart

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