Oncogenic protein tyrosine kinases: Oncogenic derivatives of platelet-derived growth factor receptors
Oncogenic protein tyrosine kinases: Oncogenic derivatives of platelet-derived growth factor receptors
Platelet-derived growth factor receptors (PDGFRs) and their ligands, platelet-derived growth factors (PDGFs) play critical roles in mesenchymal cell migration and proliferation. In embryogenesis the PDGFR/PDGF system is essential for the correct development of the kidney, cardiovascular system, brain, lung and connective tissue. In adults, PDGFR/PDGF is important in wound healing, inflammation and angiogenesis. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases, and especially malignancy. Constitutive activation of the PDGFR? or PDGFR? receptor tyrosine kinases is seen in myeloid malignancies as a consequence of fusion to diverse partner genes, and activating mutations of PDGFR? are seen in gastrointestinal tumours (GISTs). Autocrine signalling as a consequence of PDGF-B overexpression is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP) and overexpression of PDGFRs and/or their ligands has been described in many solid tumours. PDGFR signalling is inhibited by imatinib mesylate, and this compound has clear clinical activity in patients with myeloid malignancies, GIST and DFSP.
pdgfra, pdgfrb, imatinib
2912-2923
Jones, A.V.
daa5d0cf-4454-48c3-abb8-daf03aa21e8b
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
2004
Jones, A.V.
daa5d0cf-4454-48c3-abb8-daf03aa21e8b
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Jones, A.V. and Cross, N.C.P.
(2004)
Oncogenic protein tyrosine kinases: Oncogenic derivatives of platelet-derived growth factor receptors.
Cellular and Molecular Life Sciences, 61 (23), .
(doi:10.1007/s00018-004-4272-z).
Abstract
Platelet-derived growth factor receptors (PDGFRs) and their ligands, platelet-derived growth factors (PDGFs) play critical roles in mesenchymal cell migration and proliferation. In embryogenesis the PDGFR/PDGF system is essential for the correct development of the kidney, cardiovascular system, brain, lung and connective tissue. In adults, PDGFR/PDGF is important in wound healing, inflammation and angiogenesis. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases, and especially malignancy. Constitutive activation of the PDGFR? or PDGFR? receptor tyrosine kinases is seen in myeloid malignancies as a consequence of fusion to diverse partner genes, and activating mutations of PDGFR? are seen in gastrointestinal tumours (GISTs). Autocrine signalling as a consequence of PDGF-B overexpression is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP) and overexpression of PDGFRs and/or their ligands has been described in many solid tumours. PDGFR signalling is inhibited by imatinib mesylate, and this compound has clear clinical activity in patients with myeloid malignancies, GIST and DFSP.
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Published date: 2004
Keywords:
pdgfra, pdgfrb, imatinib
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Local EPrints ID: 24783
URI: http://eprints.soton.ac.uk/id/eprint/24783
ISSN: 1420-682X
PURE UUID: f50b318b-ef8f-45a1-875d-297e6fee432f
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Date deposited: 03 Apr 2006
Last modified: 16 Mar 2024 03:23
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Author:
A.V. Jones
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