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The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes

The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes
The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes
Here we correct the nucleotide sequence of a single known variant of the HLA-DRA gene. We show that the coding regions of the HLA-DRA*0101 and HLA-DRA*0102 alleles do not differ at two codons as reported previously, but only in codon 217. Using nucleotide sequencing and DNA samples from individuals homozygous in the major histocompatibility complex, we found that the variant, leucine 217-encoding HLA-DRA*0102 allele was present on the haplotypes HLA-B*0801, DRB1*03011, DQB1*0201 (ancestral haplotype AH8.1), HLA-B*07021, DRB1*15011, DQB1*0602 (AH7.1), HLA-B*1501, DRB1*15011, DQB1*0602, HLA-B*1501, DRB1*1402, DQB1*03011 and HLA-A3, B*07021, DRB1*1301, DQB1*0603. The HLA-DRA*0101 allele coding for valine 217 was observed on the haplotypes HLA-B*5701, DRB1*0701, DQB1*03032 (AH57.1), HLA-DRB1*04011, DQB1*0302, HLA-DRB1*0701, DQB1*0202, and HLA-DRB1*0101, DQB1*05011.
0001-2815
266 - 267
Kralovicova, J.
b3e0c1e7-05ed-445d-b3d9-ace11e3b4878
Marsh, S. G.
6c29e491-04ce-45d4-8859-a9770030d7ab
Waller, M. J.
2f0779c2-2332-4635-89e3-a97000f30718
Hammarstrom, L.
d3016ca1-2636-4d1f-9d68-3511aba90c2d
Vorechovsky, I.
7245de2f-8c9b-4034-8935-9a451d9b682e
Kralovicova, J.
b3e0c1e7-05ed-445d-b3d9-ace11e3b4878
Marsh, S. G.
6c29e491-04ce-45d4-8859-a9770030d7ab
Waller, M. J.
2f0779c2-2332-4635-89e3-a97000f30718
Hammarstrom, L.
d3016ca1-2636-4d1f-9d68-3511aba90c2d
Vorechovsky, I.
7245de2f-8c9b-4034-8935-9a451d9b682e

Kralovicova, J., Marsh, S. G., Waller, M. J., Hammarstrom, L. and Vorechovsky, I. (2002) The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes. Tissue Antigens, 60 (3), 266 - 267. (doi:10.1034/j.1399-0039.2002.600310.x).

Record type: Article

Abstract

Here we correct the nucleotide sequence of a single known variant of the HLA-DRA gene. We show that the coding regions of the HLA-DRA*0101 and HLA-DRA*0102 alleles do not differ at two codons as reported previously, but only in codon 217. Using nucleotide sequencing and DNA samples from individuals homozygous in the major histocompatibility complex, we found that the variant, leucine 217-encoding HLA-DRA*0102 allele was present on the haplotypes HLA-B*0801, DRB1*03011, DQB1*0201 (ancestral haplotype AH8.1), HLA-B*07021, DRB1*15011, DQB1*0602 (AH7.1), HLA-B*1501, DRB1*15011, DQB1*0602, HLA-B*1501, DRB1*1402, DQB1*03011 and HLA-A3, B*07021, DRB1*1301, DQB1*0603. The HLA-DRA*0101 allele coding for valine 217 was observed on the haplotypes HLA-B*5701, DRB1*0701, DQB1*03032 (AH57.1), HLA-DRB1*04011, DQB1*0302, HLA-DRB1*0701, DQB1*0202, and HLA-DRB1*0101, DQB1*05011.

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More information

Published date: 2002

Identifiers

Local EPrints ID: 24810
URI: http://eprints.soton.ac.uk/id/eprint/24810
ISSN: 0001-2815
PURE UUID: 01f5eae2-8c0c-4b10-a5ab-bac82005b573
ORCID for I. Vorechovsky: ORCID iD orcid.org/0000-0002-6740-6502

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Date deposited: 06 Apr 2006
Last modified: 16 Mar 2024 03:32

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Contributors

Author: J. Kralovicova
Author: S. G. Marsh
Author: M. J. Waller
Author: L. Hammarstrom
Author: I. Vorechovsky ORCID iD

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