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Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis

Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis
Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis
A recent large-scale, genome-wide association study of single nucleotide polymorphisms showed a strong association between susceptibility to myocardial infarction and the Thr26Asn polymorphism in the lymphotoxin- (LTA) gene. In the present study, we investigated whether the LTA Thr26Asn polymorphism was associated with the extent of coronary atherosclerosis in a large cohort (n=1082) of well-documented coronary artery disease patients. Thr26Asn genotypes showed a significant different distribution in male patients, when stratified according to the number of diseased coronary arteries, with an odds ratio of 1.98 (95% CI 1.22?3.22) for multiple-vessel disease in patients of the Asn/Asn genotype, compared with patients of the Thr/Thr or Thr/Asn genotype (P=0.006). Thus, further to the recent finding that LTA gene variation is associated with susceptibility to coronary heart disease, the present study provides evidence of an association between LTA genotype and the extent of coronary atherosclerosis.
lymphotoxin-d, genetics, polymorphism, atherosclerosis
1466-4879
539-541
Laxton, R.
8a44c1cc-a913-4c6f-abbd-607a9ec79575
Pearce, E.
2af3d82a-50ab-4220-9f06-31ba22f63e27
Kyriakou, T.
db580d97-b787-42e9-85d1-a1ea3d730453
Ye, S.
73027825-861c-4bca-8ce6-67a325fa2d2c
Laxton, R.
8a44c1cc-a913-4c6f-abbd-607a9ec79575
Pearce, E.
2af3d82a-50ab-4220-9f06-31ba22f63e27
Kyriakou, T.
db580d97-b787-42e9-85d1-a1ea3d730453
Ye, S.
73027825-861c-4bca-8ce6-67a325fa2d2c

Laxton, R., Pearce, E., Kyriakou, T. and Ye, S. (2005) Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis. Genes and Immunity, 6 (6), 539-541. (doi:10.1038/sj.gene.6364236).

Record type: Article

Abstract

A recent large-scale, genome-wide association study of single nucleotide polymorphisms showed a strong association between susceptibility to myocardial infarction and the Thr26Asn polymorphism in the lymphotoxin- (LTA) gene. In the present study, we investigated whether the LTA Thr26Asn polymorphism was associated with the extent of coronary atherosclerosis in a large cohort (n=1082) of well-documented coronary artery disease patients. Thr26Asn genotypes showed a significant different distribution in male patients, when stratified according to the number of diseased coronary arteries, with an odds ratio of 1.98 (95% CI 1.22?3.22) for multiple-vessel disease in patients of the Asn/Asn genotype, compared with patients of the Thr/Thr or Thr/Asn genotype (P=0.006). Thus, further to the recent finding that LTA gene variation is associated with susceptibility to coronary heart disease, the present study provides evidence of an association between LTA genotype and the extent of coronary atherosclerosis.

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Published date: 2005
Keywords: lymphotoxin-d, genetics, polymorphism, atherosclerosis

Identifiers

Local EPrints ID: 24826
URI: http://eprints.soton.ac.uk/id/eprint/24826
ISSN: 1466-4879
PURE UUID: d48ce2c0-de32-4ebc-b0ca-4f1dfa5192df

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Date deposited: 03 Apr 2006
Last modified: 15 Mar 2024 06:58

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Contributors

Author: R. Laxton
Author: E. Pearce
Author: T. Kyriakou
Author: S. Ye

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