Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation
Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation
Chronic neutrophilic leukemia (CNL) is a rare disease and can cause considerable diagnostic difficulty. Although the V617F JAK2 mutation has been described by several groups to be associated with classical myeloproliferative disorders (MPD), this same mutation has been detected with a low incidence in atypical MPD, such as CNL. Here we report the presence of the V617F mutation in a CNL patient, who is unusual for having survived for more than 96 months, with little disease progression. It remains to be established what role this mutation, which gives cells a proliferative advantage, might play in the pathogenesis and prognosis of rare atypical MPD.
1696-1697
Mc Lornan, D.P.
87963f11-e39e-4873-80af-9b5f458f4ef0
Percy, M.J.
7c380404-814a-418e-8827-44c9d7411eee
Jones, A.V.
daa5d0cf-4454-48c3-abb8-daf03aa21e8b
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Mc Mullin, M.F.
0d6f4b79-8a9f-4441-8419-ab56c5a3ec5d
2005
Mc Lornan, D.P.
87963f11-e39e-4873-80af-9b5f458f4ef0
Percy, M.J.
7c380404-814a-418e-8827-44c9d7411eee
Jones, A.V.
daa5d0cf-4454-48c3-abb8-daf03aa21e8b
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Mc Mullin, M.F.
0d6f4b79-8a9f-4441-8419-ab56c5a3ec5d
Mc Lornan, D.P., Percy, M.J., Jones, A.V., Cross, N.C. and Mc Mullin, M.F.
(2005)
Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation.
Haematologica, 90 (12), .
Abstract
Chronic neutrophilic leukemia (CNL) is a rare disease and can cause considerable diagnostic difficulty. Although the V617F JAK2 mutation has been described by several groups to be associated with classical myeloproliferative disorders (MPD), this same mutation has been detected with a low incidence in atypical MPD, such as CNL. Here we report the presence of the V617F mutation in a CNL patient, who is unusual for having survived for more than 96 months, with little disease progression. It remains to be established what role this mutation, which gives cells a proliferative advantage, might play in the pathogenesis and prognosis of rare atypical MPD.
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Published date: 2005
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Local EPrints ID: 24859
URI: http://eprints.soton.ac.uk/id/eprint/24859
ISSN: 0390-6078
PURE UUID: 30a1b17f-a7b7-4167-8755-d6da6b6d17d0
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Date deposited: 03 Apr 2006
Last modified: 23 Jul 2022 01:49
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Author:
D.P. Mc Lornan
Author:
M.J. Percy
Author:
A.V. Jones
Author:
M.F. Mc Mullin
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