Genetic epidemiology, genetic maps and positional cloning
Genetic epidemiology, genetic maps and positional cloning
Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
linkage, linkage disequilibrium, single nucleotide polymorphism, hapmap, biobank, ethics
1701-1708
Morton, Newton. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
2003
Morton, Newton. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Morton, Newton. E.
(2003)
Genetic epidemiology, genetic maps and positional cloning.
Philosophical Transactions of The Royal Society A, 358 (1438), .
(doi:10.1098/rstb.2003.1357).
Abstract
Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
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Published date: 2003
Keywords:
linkage, linkage disequilibrium, single nucleotide polymorphism, hapmap, biobank, ethics
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Local EPrints ID: 24876
URI: http://eprints.soton.ac.uk/id/eprint/24876
ISSN: 1364-503X
PURE UUID: 10a49181-0621-4201-802a-0fca7d1cc6c5
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Date deposited: 04 Apr 2006
Last modified: 15 Mar 2024 06:59
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Author:
Newton. E. Morton
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