Linkage disequilibrium maps and association mapping
Linkage disequilibrium maps and association mapping
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
1425-1430
Morton, Newton E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
1 June 2005
Morton, Newton E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Morton, Newton E.
(2005)
Linkage disequilibrium maps and association mapping.
Journal of Clinical Investigation, 115 (6), .
(doi:10.1172/JCI25032).
Abstract
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
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Published date: 1 June 2005
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Local EPrints ID: 24878
URI: http://eprints.soton.ac.uk/id/eprint/24878
ISSN: 0021-9738
PURE UUID: 077ae956-37cb-4fc1-aa4d-9bd079f166f9
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Date deposited: 04 Apr 2006
Last modified: 15 Mar 2024 06:59
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Author:
Newton E. Morton
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