Palmer, L.J., Lonjou, C., Barnes, K., Chen, H., Cookson, W.O.C.M., Deichmann, K.A., Holloway, J.W., Laitinen, T., Wjst, M. and Morton, N.E.
A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG)
Clinical & Experimental Allergy, 31, (1), . (doi:10.1046/j.1365-2222.2001.01040.x).
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Asthma is the most common chronic childhood disease in developed nations [ 1], affecting more than 155 million individuals. The cost of treating the disease in the USA alone approximates 6 billion dollars per annum [ 2]. Asthma is a complex disease that has proven extremely difficult to dissect genetically [ 3]. Considerable effort is currently being expended in attempts to detect genetic loci contributing to asthma susceptibility [ 4–7], with the ultimate goal of improving preventive strategies, diagnostic tools and therapies. However, no specific major gene exhibiting functional effects has been mapped to date.
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