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Steroidogenic factor 1: an essential mediator of endocrine development

Steroidogenic factor 1: an essential mediator of endocrine development
Steroidogenic factor 1: an essential mediator of endocrine development
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of the cytochrome P450 steroid hydroxylases, SF-1 has considerably broader roles, as evidenced from studies in knockout mice lacking SF-1. The SF-1-knockout mice lacked adrenal glands and gonads and therefore died from adrenal insufficiency within the first week after birth. In addition, SF-1 knockout mice exhibited male-to-female sex reversal of their internal and external genitalia, impaired expression of multiple markers of pituitary gonadotropes, and agenesis of the ventromedial hypothalamic nucleus (VMH). These studies delineated essential roles of SF-1 in regulating endocrine differentiation and function at multiple levels, particularly with respect to reproduction. This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function. We next discuss recent insights into the mechanisms controlling the expression and function of SF-1 as well as the current status of research aimed at delineating its roles in specific tissues. Finally, we highlight areas where additional studies are needed to expand our understanding of SF-1 action.
0079-9963
19-36
Parker, Keith L.
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Rice, Douglas A.
cfe41e91-9936-4eb6-bdaa-ea1c7b1c5e0d
Lala, Deepak S.
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Ikeda, Yayoi
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Luo, Xunrong
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Wong, Margaret
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Bakke, Marit
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Zhao, Liping
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Frigeri, Claudia
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Hanley, Neil A.
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Stallings, Nancy
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Schimmer, Bernard P.
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Parker, Keith L.
a15d4ab4-1bf6-4294-bda3-ee68245d8303
Rice, Douglas A.
cfe41e91-9936-4eb6-bdaa-ea1c7b1c5e0d
Lala, Deepak S.
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Ikeda, Yayoi
636191fb-756e-42db-ada4-81a7f3f256eb
Luo, Xunrong
ef3c23a7-68a0-4bfc-9d9e-c5cb9733f08c
Wong, Margaret
0221e74d-0670-4e41-82ec-cffb572c5713
Bakke, Marit
68d36eb7-d69a-4ec6-bde9-bdf31c971551
Zhao, Liping
a17ea846-4c1c-4047-b8dc-1145710f64ce
Frigeri, Claudia
ca933c9a-cce5-4c0d-a3a4-d75489d58f11
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Stallings, Nancy
43f44aa0-889d-437d-809e-411fef19481d
Schimmer, Bernard P.
7e201dcb-64a6-40cb-aeb3-abf9a1242d5e

Parker, Keith L., Rice, Douglas A., Lala, Deepak S., Ikeda, Yayoi, Luo, Xunrong, Wong, Margaret, Bakke, Marit, Zhao, Liping, Frigeri, Claudia, Hanley, Neil A., Stallings, Nancy and Schimmer, Bernard P. (2002) Steroidogenic factor 1: an essential mediator of endocrine development. Recent Progress in Hormone Research, 57, 19-36.

Record type: Article

Abstract

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of the cytochrome P450 steroid hydroxylases, SF-1 has considerably broader roles, as evidenced from studies in knockout mice lacking SF-1. The SF-1-knockout mice lacked adrenal glands and gonads and therefore died from adrenal insufficiency within the first week after birth. In addition, SF-1 knockout mice exhibited male-to-female sex reversal of their internal and external genitalia, impaired expression of multiple markers of pituitary gonadotropes, and agenesis of the ventromedial hypothalamic nucleus (VMH). These studies delineated essential roles of SF-1 in regulating endocrine differentiation and function at multiple levels, particularly with respect to reproduction. This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function. We next discuss recent insights into the mechanisms controlling the expression and function of SF-1 as well as the current status of research aimed at delineating its roles in specific tissues. Finally, we highlight areas where additional studies are needed to expand our understanding of SF-1 action.

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Published date: 2002

Identifiers

Local EPrints ID: 24894
URI: http://eprints.soton.ac.uk/id/eprint/24894
ISSN: 0079-9963
PURE UUID: f9ec6e38-ff9a-4fb1-bdf7-2b3eca5c3480

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Date deposited: 06 Apr 2006
Last modified: 27 Apr 2022 12:16

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Contributors

Author: Keith L. Parker
Author: Douglas A. Rice
Author: Deepak S. Lala
Author: Yayoi Ikeda
Author: Xunrong Luo
Author: Margaret Wong
Author: Marit Bakke
Author: Liping Zhao
Author: Claudia Frigeri
Author: Neil A. Hanley
Author: Nancy Stallings
Author: Bernard P. Schimmer

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