Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK
Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK
Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been reported to be associated with BP in three independent human populations, although other studies reported null associations with this trait. Our objective was to test for association between BP and genetic variation of the Y chromosome. To this end, 2,743 unrelated Caucasian men recruited from nine UK practices were analysed for five SNPs (including the HindIII site) and two microsatellites spanning the non-recombining region of the Y chromosome. Systolic and diastolic BP were analysed both as quantitative traits and as categorical variables. Differences between locations were tested. Haplotypic and linkage disequilibrium (LD) analyses were also performed. Overall, no significant association was found between any of the loci analysed and BP, although post hoc analyses suggest a possible relation of specific Y haplogroups to BP. The HindIII polymorphism marks major structural differences in the Y centromere which could infuence mitotic loss during ageing, or other somatic events. However, this study does not support a causal effect on BP, although association of one or more Y haplogroups cannot be excluded.
311-318
Rodriguez, Santiago
f235ea2b-b6f3-45e4-9fc3-5a0383689ed6
Chen, Xiao-he
fd93b896-d8cc-4b0e-a811-c0e6a8ff8308
Miller, George J.
d8e958dd-7ba2-4c1f-88c9-7d8c99747933
Day, Ian N.
083567b2-eb88-4491-b966-57fcfaf6321d
2005
Rodriguez, Santiago
f235ea2b-b6f3-45e4-9fc3-5a0383689ed6
Chen, Xiao-he
fd93b896-d8cc-4b0e-a811-c0e6a8ff8308
Miller, George J.
d8e958dd-7ba2-4c1f-88c9-7d8c99747933
Day, Ian N.
083567b2-eb88-4491-b966-57fcfaf6321d
Rodriguez, Santiago, Chen, Xiao-he, Miller, George J. and Day, Ian N.
(2005)
Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK.
Human Genetics, 116 (4), .
(doi:10.1007/s00439-004-1221-8).
Abstract
Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been reported to be associated with BP in three independent human populations, although other studies reported null associations with this trait. Our objective was to test for association between BP and genetic variation of the Y chromosome. To this end, 2,743 unrelated Caucasian men recruited from nine UK practices were analysed for five SNPs (including the HindIII site) and two microsatellites spanning the non-recombining region of the Y chromosome. Systolic and diastolic BP were analysed both as quantitative traits and as categorical variables. Differences between locations were tested. Haplotypic and linkage disequilibrium (LD) analyses were also performed. Overall, no significant association was found between any of the loci analysed and BP, although post hoc analyses suggest a possible relation of specific Y haplogroups to BP. The HindIII polymorphism marks major structural differences in the Y centromere which could infuence mitotic loss during ageing, or other somatic events. However, this study does not support a causal effect on BP, although association of one or more Y haplogroups cannot be excluded.
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Published date: 2005
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Local EPrints ID: 24928
URI: http://eprints.soton.ac.uk/id/eprint/24928
ISSN: 0340-6717
PURE UUID: 0e33d794-f981-43cd-af48-7cb676e74da8
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Date deposited: 04 Apr 2006
Last modified: 15 Mar 2024 06:59
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Author:
Santiago Rodriguez
Author:
Xiao-he Chen
Author:
George J. Miller
Author:
Ian N. Day
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