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Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis

Smith, M.P., Keay, S.D., Margo, F.C., Harlow, C.R., Wood, P.J., Cahill, D.J. and Hull, M.G. (2002) Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis American Journal of Reproductive Immunology, 47, (1), pp. 52-56.

Record type: Article


PROBLEM: To measure and compare concentrations of total and free glucocorticoids with oocyte fertilizing capacity in the follicular fluid (FF) of women with minimal–mild endometriosis and tubal damage.
METHOD OF STUDY: Follicular fluid was collected from individual periovulatory follicles during oocyte retrieval for in vitro fertilization (IVF) in natural cycles. Total and free levels of cortisol and cortisone were measured using specific radioimmunoassays after chloroform extraction.
RESULTS: Cortisol concentrations in women with minimal–mild endometriosis were significantly lower compared with controls (women with tubal infective damage) (258 versus 328 nmol/L, P < 0.02). There was no correlation between total or free concentrations of cortisol or cortisone and the fertilization capacity of the oocyte.
CONCLUSIONS: Total cortisol levels are lower in the follicles of women with endometriosis. Our findings provide further evidence of follicular dysfunction contributing to the subfertility associated with minimal–mild endometriosis.

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Published date: 2002


Local EPrints ID: 24959
ISSN: 8755-8920
PURE UUID: 96e6d940-ae1a-4c84-aee3-6b194f7e62f3

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Date deposited: 06 Apr 2006
Last modified: 17 Jul 2017 16:12

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Author: M.P. Smith
Author: S.D. Keay
Author: F.C. Margo
Author: C.R. Harlow
Author: P.J. Wood
Author: D.J. Cahill
Author: M.G. Hull

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