BAG-1: a multifunctional regulator of cell growth and survival
BAG-1: a multifunctional regulator of cell growth and survival
BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate growth control pathways important for normal and malignant cells, including apoptosis, signaling, proliferation, transcription and cell motility. Of particular relevance to tumour cells, BAG-1 interacts with the anti-apoptotic BCL-2 protein, various nuclear hormone receptors and the 70 kDa heat shock proteins, Hsc70 and Hsp70. Interaction with chaperones may account for many of the pleiotropic effects associated with BAG-1 overexpression. Recent studies have shown that BAG-1 expression is frequently altered in malignant cells, and BAG-1 expression may have clinical value as a prognostic/predictive marker. This review summarises current understanding of molecular mechanisms of BAG-1 expression and function.
BAG-1, cancer, heat shock protein, apoptosis, nuclear hormone receptor
83-98
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Cutress, Ramsey I.
68ae4f86-e8cf-411f-a335-cdba51797406
Sharp, Adam
f26a1894-b10f-4864-a314-750628d6c0cc
Brimmell, Matthew
4bb675a5-c3f0-4ddb-ae49-d39257ba79e1
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
2003
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Cutress, Ramsey I.
68ae4f86-e8cf-411f-a335-cdba51797406
Sharp, Adam
f26a1894-b10f-4864-a314-750628d6c0cc
Brimmell, Matthew
4bb675a5-c3f0-4ddb-ae49-d39257ba79e1
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Townsend, Paul A., Cutress, Ramsey I., Sharp, Adam, Brimmell, Matthew and Packham, Graham
(2003)
BAG-1: a multifunctional regulator of cell growth and survival.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1603 (2), .
(doi:10.1016/S0304-419X(03)00002-7).
(PMID:12618309)
Abstract
BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate growth control pathways important for normal and malignant cells, including apoptosis, signaling, proliferation, transcription and cell motility. Of particular relevance to tumour cells, BAG-1 interacts with the anti-apoptotic BCL-2 protein, various nuclear hormone receptors and the 70 kDa heat shock proteins, Hsc70 and Hsp70. Interaction with chaperones may account for many of the pleiotropic effects associated with BAG-1 overexpression. Recent studies have shown that BAG-1 expression is frequently altered in malignant cells, and BAG-1 expression may have clinical value as a prognostic/predictive marker. This review summarises current understanding of molecular mechanisms of BAG-1 expression and function.
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Published date: 2003
Keywords:
BAG-1, cancer, heat shock protein, apoptosis, nuclear hormone receptor
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Local EPrints ID: 24995
URI: http://eprints.soton.ac.uk/id/eprint/24995
ISSN: 0304-419X
PURE UUID: 26ef56e3-800e-42f4-9b7d-677aa2168304
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Date deposited: 05 Apr 2006
Last modified: 16 Mar 2024 03:14
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Author:
Paul A. Townsend
Author:
Adam Sharp
Author:
Matthew Brimmell
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