Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases
Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases
We report two new cases with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion. Case 1 presented with polycythaemia vera (PV) and evolved over 4 years to a myeloproliferative disorder (MPD) resembling the 8p11 myeloproliferative syndrome (EMS). Case 2 presented
with B-cell lymphoblastic leukaemia (B-ALL). These cases illustrate the clinical heterogeneity observed in patients with FGFR1 rearrangements and suggest that constitutively activated
tyrosine kinases may be more widespread in MPDs.
FGFRI fusion, polycythaemia vera, myeloproliferative disorders
534-537
Vizmanos, J.L.
07c37419-074d-4b69-b0c8-11c69f76749c
Hernandez, R.
196a605a-0305-4c38-a3c2-28b34d2215fb
Vidal, M.J.
06cc30f6-8276-4afe-a1b2-eaffefde2afd
Larrayoz, M.J.
16234ce2-84fe-40f8-b49e-9d7e2bf243e0
Odero, M.D.
9ede17ad-fbe3-4c80-ab45-e19507abe082
Marin, J.
bad8bec5-3e07-47ed-9e87-5c95fbe99c28
Ardanaz, M.T.
f9eb1172-8fbc-412a-abc9-6816f90d28e1
Calasanz, M.J.
dcc04295-5a46-440f-a53a-7fcdb92ba9ef
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
2004
Vizmanos, J.L.
07c37419-074d-4b69-b0c8-11c69f76749c
Hernandez, R.
196a605a-0305-4c38-a3c2-28b34d2215fb
Vidal, M.J.
06cc30f6-8276-4afe-a1b2-eaffefde2afd
Larrayoz, M.J.
16234ce2-84fe-40f8-b49e-9d7e2bf243e0
Odero, M.D.
9ede17ad-fbe3-4c80-ab45-e19507abe082
Marin, J.
bad8bec5-3e07-47ed-9e87-5c95fbe99c28
Ardanaz, M.T.
f9eb1172-8fbc-412a-abc9-6816f90d28e1
Calasanz, M.J.
dcc04295-5a46-440f-a53a-7fcdb92ba9ef
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Vizmanos, J.L., Hernandez, R., Vidal, M.J., Larrayoz, M.J., Odero, M.D., Marin, J., Ardanaz, M.T., Calasanz, M.J. and Cross, N.C.P.
(2004)
Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases.
The Hematology Journal, 5 (6), .
(doi:10.1038/sj.thj.6200561).
Abstract
We report two new cases with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion. Case 1 presented with polycythaemia vera (PV) and evolved over 4 years to a myeloproliferative disorder (MPD) resembling the 8p11 myeloproliferative syndrome (EMS). Case 2 presented
with B-cell lymphoblastic leukaemia (B-ALL). These cases illustrate the clinical heterogeneity observed in patients with FGFR1 rearrangements and suggest that constitutively activated
tyrosine kinases may be more widespread in MPDs.
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Published date: 2004
Additional Information:
Case Report
Keywords:
FGFRI fusion, polycythaemia vera, myeloproliferative disorders
Identifiers
Local EPrints ID: 25014
URI: http://eprints.soton.ac.uk/id/eprint/25014
ISSN: 1466-4680
PURE UUID: 46c67bd4-e148-48a6-b386-35ccb5c65f88
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Date deposited: 05 Apr 2006
Last modified: 16 Mar 2024 03:23
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Contributors
Author:
J.L. Vizmanos
Author:
R. Hernandez
Author:
M.J. Vidal
Author:
M.J. Larrayoz
Author:
M.D. Odero
Author:
J. Marin
Author:
M.T. Ardanaz
Author:
M.J. Calasanz
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