Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome
Data have been accumulating that indicate that matrix metalloproteinase (MMP) gene polymorphisms contribute to inter-individual differences in susceptibility to and outcome of cardiovascular disease. This is currently best exemplified by the MMP3 gene 5A/6A polymorphism which has an effect on MMP3 expression and has been shown to be associated with coronary stenosis, myocardial infarction, coronary artery calcification, post-angioplasty coronary restenosis, carotid atherosclerosis, stroke, arterial stiffness, and blood pressure. Functional polymorphisms in the MMP1, MMP2, MMP7, MMP9, MMP12, and MMP13 genes have also been related to coronary artery disease, arterial stiffness, and/or abdominal aortic aneurysm. These genetic findings support the notion that MMPs play important roles in the pathogenesis of these conditions. There is also some evidence suggesting that MMP genotyping could aid in identifying patients who are likely to have unfavourable prognosis and/or adverse response to treatment.
matrix metalloproteinase, genetics, polymorphisms, cardiovascular disease
636-645
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
2006
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Ye, Shu
(2006)
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.
Cardiovascular Research, 69 (3), .
(doi:10.1016/j.cardiores.2005.07.015).
Abstract
Data have been accumulating that indicate that matrix metalloproteinase (MMP) gene polymorphisms contribute to inter-individual differences in susceptibility to and outcome of cardiovascular disease. This is currently best exemplified by the MMP3 gene 5A/6A polymorphism which has an effect on MMP3 expression and has been shown to be associated with coronary stenosis, myocardial infarction, coronary artery calcification, post-angioplasty coronary restenosis, carotid atherosclerosis, stroke, arterial stiffness, and blood pressure. Functional polymorphisms in the MMP1, MMP2, MMP7, MMP9, MMP12, and MMP13 genes have also been related to coronary artery disease, arterial stiffness, and/or abdominal aortic aneurysm. These genetic findings support the notion that MMPs play important roles in the pathogenesis of these conditions. There is also some evidence suggesting that MMP genotyping could aid in identifying patients who are likely to have unfavourable prognosis and/or adverse response to treatment.
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Published date: 2006
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Keywords:
matrix metalloproteinase, genetics, polymorphisms, cardiovascular disease
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Local EPrints ID: 25050
URI: http://eprints.soton.ac.uk/id/eprint/25050
ISSN: 0008-6363
PURE UUID: 013d67d3-2b12-4440-bdc9-74488468f08b
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Date deposited: 03 Apr 2006
Last modified: 15 Mar 2024 07:00
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Author:
Shu Ye
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