Mapping quantitative effects of oligogenes by allelic association
Mapping quantitative effects of oligogenes by allelic association
Regression analysis of a quantitative trait as a function of a single diallelic polymorphism has been extended to allelic association by composite likelihood under the Malecot model for multiple markers. We applied the method to 10 single nucleotide polymorphisms (SNPs) spanning 27 kb of the angiotensin-I converting enzyme (ACE) gene in British families, localising a causal SNP between G2530A and 4656(CT)3/2 in the 3' region, at a distance of 21.6±0.9 kb from the most proximal SNP T-5491C. Neither they nor the I/D polymorphism is causal. To clarify genetic parameters we applied combined segregation, linkage and association analysis. Stronger evidence for the 3' region was obtained, with significant evidence of a lesser 5' effect as reported in French and Nigerian families. However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms.
211-221
Zhang, W.
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Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Abecasis, G.R.
e1050756-f0d0-4420-8dc6-b759903b01de
Cardon, L.R.
9be43f10-8360-4c6c-8f79-1427a0ff474e
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
May 2002
Zhang, W.
1c80d4f2-4ba8-41f6-85a6-a76a4d65dc9b
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Abecasis, G.R.
e1050756-f0d0-4420-8dc6-b759903b01de
Cardon, L.R.
9be43f10-8360-4c6c-8f79-1427a0ff474e
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Zhang, W., Collins, A., Abecasis, G.R., Cardon, L.R. and Morton, N.E.
(2002)
Mapping quantitative effects of oligogenes by allelic association.
Annals of Human Genetics, 66 (3), .
(doi:10.1046/j.1469-1809.2002.00111.x).
Abstract
Regression analysis of a quantitative trait as a function of a single diallelic polymorphism has been extended to allelic association by composite likelihood under the Malecot model for multiple markers. We applied the method to 10 single nucleotide polymorphisms (SNPs) spanning 27 kb of the angiotensin-I converting enzyme (ACE) gene in British families, localising a causal SNP between G2530A and 4656(CT)3/2 in the 3' region, at a distance of 21.6±0.9 kb from the most proximal SNP T-5491C. Neither they nor the I/D polymorphism is causal. To clarify genetic parameters we applied combined segregation, linkage and association analysis. Stronger evidence for the 3' region was obtained, with significant evidence of a lesser 5' effect as reported in French and Nigerian families. However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms.
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Published date: May 2002
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Local EPrints ID: 25065
URI: http://eprints.soton.ac.uk/id/eprint/25065
ISSN: 0003-4800
PURE UUID: fe398d68-5c09-41dd-b2c6-23d280a13502
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Date deposited: 06 Apr 2006
Last modified: 16 Mar 2024 02:42
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Contributors
Author:
W. Zhang
Author:
G.R. Abecasis
Author:
L.R. Cardon
Author:
N.E. Morton
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