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Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits

Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits
Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits
Background: The renin angiotensin system is important in the regulation of vascular tone and fluid and electrolyte balance. The angiotensin converting enzyme gene (ACE) genotype has been shown to affect exercise response and glucose load response dependent on birth weight. Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated.

Method: AGTR1 A1166C was genotyped by allele specific PCR in 378 individuals from Hertfordshire, UK, who had been characterised for metabolic syndrome traits.

Results: Genotype counts were: AA, 183; AC, 170; CC, 25, consistent with Hardy-Weinberg equilibrium. The CC genotype was associated with significantly lower body mass index (by 1.7 units) in men (p = 0.03), and the same magnitude effect in women with significant lower weight in both genders (p = 0.01), also lower waist circumference and waist-hip ratio (p = 0.01) in men, with a trend for lower waist circumference in women also. Additionally, the CC genotype and/or C allele was associated with lower fasting glucose and insulin, and 30 and 120 min glucose in men (respectively, p = 0.08, 0.04, 0.01, 0.06). Lower means of systolic blood pressure, pulse pressure, cholesterol, and fasting triglyceride were also observed for the CC genotype in both genders though these were not statistically significant.

Conclusions: The AGTR1 1166 CC genotype appears to predispose to favourable anthropometric and metabolic traits, relative to cardiovascular risk.
ace, agtr1 a1166c, angiotensin ii type i receptor, metabolic and anthropometric traits
0022-2593
396-401
Abdollahi, M.R.
96ec68db-6302-4216-9aaf-9951a44be8b8
Gaunt, T.R.
0867a942-06a8-4e40-9c97-c47124d474e9
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Ye, S.
73027825-861c-4bca-8ce6-67a325fa2d2c
Day, I.N.M.
1a55713e-ee42-4f9c-9867-955202528f17
Abdollahi, M.R.
96ec68db-6302-4216-9aaf-9951a44be8b8
Gaunt, T.R.
0867a942-06a8-4e40-9c97-c47124d474e9
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Ye, S.
73027825-861c-4bca-8ce6-67a325fa2d2c
Day, I.N.M.
1a55713e-ee42-4f9c-9867-955202528f17

Abdollahi, M.R., Gaunt, T.R., Syddall, H.E., Cooper, C., Phillips, D.I.W., Ye, S. and Day, I.N.M. (2005) Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. Journal of Medical Genetics, 42 (5), 396-401. (doi:10.1136/jmg.2004.026716). (PMID:15863668)

Record type: Article

Abstract

Background: The renin angiotensin system is important in the regulation of vascular tone and fluid and electrolyte balance. The angiotensin converting enzyme gene (ACE) genotype has been shown to affect exercise response and glucose load response dependent on birth weight. Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated.

Method: AGTR1 A1166C was genotyped by allele specific PCR in 378 individuals from Hertfordshire, UK, who had been characterised for metabolic syndrome traits.

Results: Genotype counts were: AA, 183; AC, 170; CC, 25, consistent with Hardy-Weinberg equilibrium. The CC genotype was associated with significantly lower body mass index (by 1.7 units) in men (p = 0.03), and the same magnitude effect in women with significant lower weight in both genders (p = 0.01), also lower waist circumference and waist-hip ratio (p = 0.01) in men, with a trend for lower waist circumference in women also. Additionally, the CC genotype and/or C allele was associated with lower fasting glucose and insulin, and 30 and 120 min glucose in men (respectively, p = 0.08, 0.04, 0.01, 0.06). Lower means of systolic blood pressure, pulse pressure, cholesterol, and fasting triglyceride were also observed for the CC genotype in both genders though these were not statistically significant.

Conclusions: The AGTR1 1166 CC genotype appears to predispose to favourable anthropometric and metabolic traits, relative to cardiovascular risk.

Full text not available from this repository.

More information

Published date: May 2005
Keywords: ace, agtr1 a1166c, angiotensin ii type i receptor, metabolic and anthropometric traits
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 25177
URI: http://eprints.soton.ac.uk/id/eprint/25177
ISSN: 0022-2593
PURE UUID: a8f0b6ff-e4fe-4c6c-8084-439466e1958e
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 06 Apr 2006
Last modified: 10 Dec 2019 01:52

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