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Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake

Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake
Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake
The plasma concentrations of albumin, HDL apolipoprotein A1 (apoA1), retinol-binding protein (RBP), transthyretin (TTR), haptoglobulin, and fibrinogen were measured, and a stable isotope infusion protocol was used to determine the fractional and absolute synthesis rates of RBP, TTR, and fibrinogen in 12 young adults on three occasions during a reduction of their habitual protein intake from 1.13 to 0.75 g·kg–1·day–1 for 10 days. This study was performed to determine whether healthy adults could maintain the rates of synthesis of selected nutrient transport and positive acute-phase proteins when consuming a protein intake of 0.75 g·kg–1·day–1. During the lower protein intake, the plasma concentration of all the proteins, other than HDL-apoA1, remained unchanged. HDL-apoA1 concentration was significantly reduced (P < 0.05) after 3 days of the lower protein intake, but not at 10 days. The rates of synthesis of RBP and TTR declined significantly (P < 0.05), whereas the rate of synthesis of fibrinogen remained unchanged. The results indicate that, when normal adults consume the recommended safe level of protein, 0.75 g·kg–1·day–1, there is a slower rate of turnover of nutrient transport proteins than on their habitual diet. Hence, healthy individuals consuming this amount of protein may be less able to mount an adequate metabolic response to a stressful stimulus.
protein requirements, acute-phase proteins, nutrient transport proteins
0193-1849
E327-E330
Afolabi, Paul R.
757e7f01-664c-493e-bc51-c6a2c933dc22
Jahoor, Farook
7b3a0b55-f1a0-4dbd-bc48-d031a87a4ef0
Gibson, Neil R.
78736858-f72c-48e7-ae49-4a5519ffb3e4
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Afolabi, Paul R.
757e7f01-664c-493e-bc51-c6a2c933dc22
Jahoor, Farook
7b3a0b55-f1a0-4dbd-bc48-d031a87a4ef0
Gibson, Neil R.
78736858-f72c-48e7-ae49-4a5519ffb3e4
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef

Afolabi, Paul R., Jahoor, Farook, Gibson, Neil R. and Jackson, Alan A. (2004) Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake. American Journal of Physiology: Endocrinology and Metabolism, 287 (2), E327-E330. (doi:10.1152/ajpendo.00036.2004).

Record type: Article

Abstract

The plasma concentrations of albumin, HDL apolipoprotein A1 (apoA1), retinol-binding protein (RBP), transthyretin (TTR), haptoglobulin, and fibrinogen were measured, and a stable isotope infusion protocol was used to determine the fractional and absolute synthesis rates of RBP, TTR, and fibrinogen in 12 young adults on three occasions during a reduction of their habitual protein intake from 1.13 to 0.75 g·kg–1·day–1 for 10 days. This study was performed to determine whether healthy adults could maintain the rates of synthesis of selected nutrient transport and positive acute-phase proteins when consuming a protein intake of 0.75 g·kg–1·day–1. During the lower protein intake, the plasma concentration of all the proteins, other than HDL-apoA1, remained unchanged. HDL-apoA1 concentration was significantly reduced (P < 0.05) after 3 days of the lower protein intake, but not at 10 days. The rates of synthesis of RBP and TTR declined significantly (P < 0.05), whereas the rate of synthesis of fibrinogen remained unchanged. The results indicate that, when normal adults consume the recommended safe level of protein, 0.75 g·kg–1·day–1, there is a slower rate of turnover of nutrient transport proteins than on their habitual diet. Hence, healthy individuals consuming this amount of protein may be less able to mount an adequate metabolic response to a stressful stimulus.

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More information

Published date: 2004
Keywords: protein requirements, acute-phase proteins, nutrient transport proteins

Identifiers

Local EPrints ID: 25180
URI: http://eprints.soton.ac.uk/id/eprint/25180
ISSN: 0193-1849
PURE UUID: ed1167b5-79ba-4fd3-8c0c-6100accb39e4
ORCID for Paul R. Afolabi: ORCID iD orcid.org/0000-0002-0553-1578

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Date deposited: 06 Apr 2006
Last modified: 16 Mar 2024 02:51

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Contributors

Author: Paul R. Afolabi ORCID iD
Author: Farook Jahoor
Author: Neil R. Gibson
Author: Alan A. Jackson

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