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Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis

Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis
Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis
Objective To determine the influence of body weight throughout the life course on the development of clinical hand osteoarthritis (OA).
Methods A British national survey was used to perform a prospective cohort study of 1,467 men and 1,519 women born in 1946. Weight was measured at birth and at subsequent followup visits through childhood and adulthood. The main outcome measure was the odds ratio for the presence of hand OA at the age of 53 years.
Results Two hundred eighty men (19%) and 458 women (30%) had OA in at least 1 hand joint. Hand OA was significantly associated with increased weight at ages 26 years, 43 years, and 53 years and with decreased weight at birth in men. Birth weight and adult weight showed independent effects, such that men with the highest risk for OA represented those who had been heaviest at age 53 years and lightest at birth. These findings were not explained by grip strength. There was no significant relationship between weight and hand OA in women.
Conclusion The results of this study show that increased adult weight is associated with, and may precede, development of hand OA in men. An association between hand OA and weight was not observed in women. The relationship between hand OA and decreased birth weight is a new finding and may reflect the persisting influence of prenatal environmental factors on adult joint structure and function.
0004-3591
1030-1033
Aihie-Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Cox, V.
ff42143b-7eb8-4573-9bdf-ca3ade40a634
Kuh, D.
6c5d95a4-433d-4895-bd95-86a7d5fe76a5
Hardy, R.
b3f0f66e-4cda-4e9a-aca1-955f7ecdd132
Wadsworth, M.
999169a5-826c-4444-b1a9-2a1d06865020
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie-Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Poole, J.
d6c5377d-ac31-4552-8108-e5bd16f9fd00
Cox, V.
ff42143b-7eb8-4573-9bdf-ca3ade40a634
Kuh, D.
6c5d95a4-433d-4895-bd95-86a7d5fe76a5
Hardy, R.
b3f0f66e-4cda-4e9a-aca1-955f7ecdd132
Wadsworth, M.
999169a5-826c-4444-b1a9-2a1d06865020
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Aihie-Sayer, A., Poole, J., Cox, V., Kuh, D., Hardy, R., Wadsworth, M. and Cooper, C. (2003) Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis & Rheumatism, 48 (4), 1030-1033. (doi:10.1002/art.10862).

Record type: Article

Abstract

Objective To determine the influence of body weight throughout the life course on the development of clinical hand osteoarthritis (OA).
Methods A British national survey was used to perform a prospective cohort study of 1,467 men and 1,519 women born in 1946. Weight was measured at birth and at subsequent followup visits through childhood and adulthood. The main outcome measure was the odds ratio for the presence of hand OA at the age of 53 years.
Results Two hundred eighty men (19%) and 458 women (30%) had OA in at least 1 hand joint. Hand OA was significantly associated with increased weight at ages 26 years, 43 years, and 53 years and with decreased weight at birth in men. Birth weight and adult weight showed independent effects, such that men with the highest risk for OA represented those who had been heaviest at age 53 years and lightest at birth. These findings were not explained by grip strength. There was no significant relationship between weight and hand OA in women.
Conclusion The results of this study show that increased adult weight is associated with, and may precede, development of hand OA in men. An association between hand OA and weight was not observed in women. The relationship between hand OA and decreased birth weight is a new finding and may reflect the persisting influence of prenatal environmental factors on adult joint structure and function.

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More information

Published date: 2003
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25188
URI: https://eprints.soton.ac.uk/id/eprint/25188
ISSN: 0004-3591
PURE UUID: f2c41a57-6de3-4420-b134-159900aacbfa
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 06 Apr 2006
Last modified: 06 Jun 2018 12:59

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