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Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D

Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D
Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D
Background: Adult bone mineral status is modified by early environmental influences, but the mechanism of this phenomenon is unknown. Intestinal calcium absorption and vitamin D metabolism are integrally involved in bone metabolism and may be programmed during early life.
Aim: To examine the early-life influences on calcium absorption and its control in 322 post-menopausal female twins.
Methods: Intestinal calcium absorption was assessed by the stable strontium (Sr) method. Serum PTH, 25(OH) and 1,25(OH)2 vitamin D were measured and recalled birth weight recorded.
Results: Fractional intestinal Sr absorption (alphaSr) was correlated with serum 1,25(OH)2 vitamin D (p<0.001), but not with 25(OH) vitamin D. Birth weight was inversely associated with serum 1,25(OH)2 vitamin D (p=0.04), the association being independent of serum calcium, phosphate, creatinine and PTH. Birth weight was inversely correlated with alphaSr (p=0.03), this association being independent of age, season, customary calcium intake and serum 25(OH) vitamin D; however, when serum 1,25(OH)2 vitamin D was added into the model, the association became non-significant, suggesting that the association was partially mediated via serum 1,25(OH)2 vitamin D.
Discussion: We found a significant inverse association between birth weight and intestinal calcium absorption that is partially explained by an association between serum 1,25(OH)2 vitamin D and birth weight. This suggests a mechanism whereby the intra-uterine environment might affect adult skeletal status.
1460-2725
15-21
Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f
Major, P.
07c6f4a5-d1f5-4133-9f1c-ce4c3cf94791
Poole, J. R.
4167399c-4428-4b09-a50e-9e5bed6c61ed
Keen, R. W.
01a2c55e-15e9-4d3c-85ee-817861408dc8
Vaja, S.
72a20ab0-f08e-4aa6-922c-cc0b76b58491
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Spector, T. D.
29debf10-949d-4094-8f5f-9a8614511ccb
Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f
Major, P.
07c6f4a5-d1f5-4133-9f1c-ce4c3cf94791
Poole, J. R.
4167399c-4428-4b09-a50e-9e5bed6c61ed
Keen, R. W.
01a2c55e-15e9-4d3c-85ee-817861408dc8
Vaja, S.
72a20ab0-f08e-4aa6-922c-cc0b76b58491
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Spector, T. D.
29debf10-949d-4094-8f5f-9a8614511ccb

Arden, N. K., Major, P., Poole, J. R., Keen, R. W., Vaja, S., Swaminathan, R., Cooper, C. and Spector, T. D. (2002) Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D. QJM: An International Journal of Medicine, 95 (1), 15-21.

Record type: Article

Abstract

Background: Adult bone mineral status is modified by early environmental influences, but the mechanism of this phenomenon is unknown. Intestinal calcium absorption and vitamin D metabolism are integrally involved in bone metabolism and may be programmed during early life.
Aim: To examine the early-life influences on calcium absorption and its control in 322 post-menopausal female twins.
Methods: Intestinal calcium absorption was assessed by the stable strontium (Sr) method. Serum PTH, 25(OH) and 1,25(OH)2 vitamin D were measured and recalled birth weight recorded.
Results: Fractional intestinal Sr absorption (alphaSr) was correlated with serum 1,25(OH)2 vitamin D (p<0.001), but not with 25(OH) vitamin D. Birth weight was inversely associated with serum 1,25(OH)2 vitamin D (p=0.04), the association being independent of serum calcium, phosphate, creatinine and PTH. Birth weight was inversely correlated with alphaSr (p=0.03), this association being independent of age, season, customary calcium intake and serum 25(OH) vitamin D; however, when serum 1,25(OH)2 vitamin D was added into the model, the association became non-significant, suggesting that the association was partially mediated via serum 1,25(OH)2 vitamin D.
Discussion: We found a significant inverse association between birth weight and intestinal calcium absorption that is partially explained by an association between serum 1,25(OH)2 vitamin D and birth weight. This suggests a mechanism whereby the intra-uterine environment might affect adult skeletal status.

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Published date: 2002

Identifiers

Local EPrints ID: 25202
URI: http://eprints.soton.ac.uk/id/eprint/25202
ISSN: 1460-2725
PURE UUID: ed256f87-b23a-42ea-8119-4b5b2d1af3e6
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 07 Apr 2006
Last modified: 17 Dec 2019 01:56

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