Early life influences on serum 1,25 (OH) vitamin D
Early life influences on serum 1,25 (OH) vitamin D
There is increasing evidence to support the role of the intrauterine and early postnatal environment in determining adult bone mass and risk of fracture. The mechanisms by which this occurs are uncertain but include perturbations in several endocrine axes. Vitamin D is integrally involved in bone metabolism and is therefore an ideal candidate. This study assesses whether birthweight and weight at 1 year of age are associated with the calcium vitamin D axis in elderly women.
Vitamin D metabolites, parathyroid hormone, bone mineral density and biochemical markers of bone turnover were measured in 129 healthy women (mean age 65.5 years) from the MRC Hertfordshire Cohort Study whose birthweight and weight at 1 year were available from records.
Serum 1,25 (OH)2 vitamin D concentrations were reduced with increasing weight at 1 year (19.1% reduction between the lowest and highest tertiles, P < 0.01). A similar, but weaker trend was seen for birthweight. These associations were not explained by serum levels of serum calcium, phosphate, PTH, creatinine or sex hormones. The association of serum calcium with 1,25 (OH)2 vitamin D was greatest in the lowest tertile with little association in the highest tertile suggesting an increased sensitivity of renal 1-? hydroxylase in the lowest tertile. Highest levels of 1,25 (OH)2 vitamin D were associated with low BMD and high levels of urinary N-telopeptide suggesting that vitamin D metabolism may mediate the intrauterine and early postnatal environmental effects on adult BMD.
36-42
Arden, Nigel K.
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Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Javaid, Muhammad K.
96dface0-b6e3-47f0-8365-7f22f33a2022
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
2005
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Javaid, Muhammad K.
96dface0-b6e3-47f0-8365-7f22f33a2022
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, Nigel K., Syddall, Holly E., Javaid, Muhammad K., Dennison, Elaine M., Swaminathan, R., Fall, Caroline and Cooper, Cyrus
(2005)
Early life influences on serum 1,25 (OH) vitamin D.
Paediatric and Perinatal Epidemiology, 19 (1), .
(doi:10.1111/j.1365-3016.2004.00618.x).
Abstract
There is increasing evidence to support the role of the intrauterine and early postnatal environment in determining adult bone mass and risk of fracture. The mechanisms by which this occurs are uncertain but include perturbations in several endocrine axes. Vitamin D is integrally involved in bone metabolism and is therefore an ideal candidate. This study assesses whether birthweight and weight at 1 year of age are associated with the calcium vitamin D axis in elderly women.
Vitamin D metabolites, parathyroid hormone, bone mineral density and biochemical markers of bone turnover were measured in 129 healthy women (mean age 65.5 years) from the MRC Hertfordshire Cohort Study whose birthweight and weight at 1 year were available from records.
Serum 1,25 (OH)2 vitamin D concentrations were reduced with increasing weight at 1 year (19.1% reduction between the lowest and highest tertiles, P < 0.01). A similar, but weaker trend was seen for birthweight. These associations were not explained by serum levels of serum calcium, phosphate, PTH, creatinine or sex hormones. The association of serum calcium with 1,25 (OH)2 vitamin D was greatest in the lowest tertile with little association in the highest tertile suggesting an increased sensitivity of renal 1-? hydroxylase in the lowest tertile. Highest levels of 1,25 (OH)2 vitamin D were associated with low BMD and high levels of urinary N-telopeptide suggesting that vitamin D metabolism may mediate the intrauterine and early postnatal environmental effects on adult BMD.
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Published date: 2005
Identifiers
Local EPrints ID: 25205
URI: http://eprints.soton.ac.uk/id/eprint/25205
ISSN: 0269-5022
PURE UUID: 630141ab-f3de-4f0c-87fc-d7c1ae674cd2
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Date deposited: 11 Apr 2006
Last modified: 18 Mar 2024 02:48
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Author:
Muhammad K. Javaid
Author:
R. Swaminathan
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