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Melioidosis in systemic lupus erythematosus: the importance of early diagnosis and treatment in patients from endemic areas

Badsha, H., Edwards, C.J. and Chng, H.H. (2001) Melioidosis in systemic lupus erythematosus: the importance of early diagnosis and treatment in patients from endemic areas Lupus, 10, (11), pp. 821-823.

Record type: Article

Abstract

Serious infection is a common problem in immunosuppressed patients with systemic lupus erythematosus (SLE). Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei and may present as an acute fulminant pneumonia or septicaemia that is often fatal. The organism is endemic in much of South-east Asia but is being increasingly reported from other parts of the world, including India, Northern Australia and North and South America. In addition to occurring in people who come into contact with contaminated soil or water in endemic areas, the infection is more common in immunosuppressed patients and must be recognised early and treated with appropriate antibiotics. Importantly, it can activate many years after the initial exposure, causing diagnostic confusion. We present the cases of three patients with SLE who were admitted with fever and in whom Burkholderia pseudomallei was isolated from blood cultures. Following treatment with intravenous ceftazidime all patients made a good recovery. These cases demonstrate the importance of considering this infectious organism in patients from endemic areas with unexplained fever. They also illustrate how successful outcomes can be achieved in a frequently fatal disease if an early diagnosis is made and appropriate antibiotics are started promptly.

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More information

Published date: 2001
Keywords: melioidosis, infection, burkholderia psuedomallei

Identifiers

Local EPrints ID: 25209
URI: http://eprints.soton.ac.uk/id/eprint/25209
PURE UUID: 46685b61-857c-4c6f-acd1-d3dbdbe44f16

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 17 Jul 2017 16:11

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Contributors

Author: H. Badsha
Author: C.J. Edwards
Author: H.H. Chng

University divisions

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