Coronary heart disease: a disorder of growth
Coronary heart disease: a disorder of growth
A new 'developmental' model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop these disorders have altered growth in utero, during infancy and childhood provides a new starting point for research. The immediate prospect for prevention is through protecting infant growth and preventing accelerated weight gain in children made vulnerable to later disease by small size at birth and during infancy. Ultimately we need to optimize maternal diet and composition before and during pregnancy. Despite current levels of nutrition in Western countries the nutrition of many fetuses and infants remains suboptimal because the nutrients available are unbalanced or because their delivery is constrained by the long and vulnerable fetal supply line.
coronary heart disease, fetal and childhood growth, developmental plasticity
35-41
Barker, D. J. P.
963dd42f-0bfc-46f5-87b0-1ba13c545500
2003
Barker, D. J. P.
963dd42f-0bfc-46f5-87b0-1ba13c545500
Barker, D. J. P.
(2003)
Coronary heart disease: a disorder of growth.
Hormone Research, 59 (Supp.1), .
(doi:10.1159/000067843).
Abstract
A new 'developmental' model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop these disorders have altered growth in utero, during infancy and childhood provides a new starting point for research. The immediate prospect for prevention is through protecting infant growth and preventing accelerated weight gain in children made vulnerable to later disease by small size at birth and during infancy. Ultimately we need to optimize maternal diet and composition before and during pregnancy. Despite current levels of nutrition in Western countries the nutrition of many fetuses and infants remains suboptimal because the nutrients available are unbalanced or because their delivery is constrained by the long and vulnerable fetal supply line.
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Published date: 2003
Additional Information:
Supplement is also available as: ISBN 3-8055-7539-4
Proceedings of the 13th Novo Nordisk Symposium on Growth Hormone and Endocrinology
Budapest, April 12-13, 2002
and Proceedings of the SGA/IUGR Satellite Symposium
Budapest, April 11, 2002
Editors: M.B. Ranke, Tübingen; J.S. Christiansen, Aarhus
Keywords:
coronary heart disease, fetal and childhood growth, developmental plasticity
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Local EPrints ID: 25230
URI: http://eprints.soton.ac.uk/id/eprint/25230
ISSN: 0301-0163
PURE UUID: 03fab6b6-d61b-4d76-a44d-213a9c713b5d
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Date deposited: 07 Apr 2006
Last modified: 15 Mar 2024 07:01
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D. J. P. Barker
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