The University of Southampton
University of Southampton Institutional Repository

The developmental origins of well-being

Barker, D. J. P. (2004) The developmental origins of well-being Philosophical Transactions A, 359, (1449), pp. 1359-1366. (doi:10.1098/rstb.2004.1518).

Record type: Article


Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders, stroke, hypertension and adult-onset diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. A new vision of optimal early human development is emerging, which takes account of health and well-being throughout life.

Full text not available from this repository.

More information

Published date: 2004
Additional Information: One contribution of 12 to a Discussion Meeting Issue 'The science of well-being: integrating neurobiology, psychology and social science'.
Keywords: developmental plasticity, chronic disease, reproductive fitness


Local EPrints ID: 25238
ISSN: 0962-8436
PURE UUID: a5ca7671-1cc3-4a42-aa80-bf23aeefb99a

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 17 Jul 2017 16:11

Export record


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.