The University of Southampton
University of Southampton Institutional Repository

The developmental origins of adult disease

The developmental origins of adult disease
The developmental origins of adult disease
Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes.
maternal diet, developmental origins of disease, or developmental origins, cardiovascular disease, low birthweight
588S-595S
Barker, D.J.P.
64c6005a-eea7-4c26-8f07-50d875998512
Barker, D.J.P.
64c6005a-eea7-4c26-8f07-50d875998512

Barker, D.J.P. (2004) The developmental origins of adult disease. Journal of the American College of Nutrition, 23 (6 Suppl), 588S-595S.

Record type: Article

Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes.

This record has no associated files available for download.

More information

Published date: December 2004
Keywords: maternal diet, developmental origins of disease, or developmental origins, cardiovascular disease, low birthweight

Identifiers

Local EPrints ID: 25239
URI: http://eprints.soton.ac.uk/id/eprint/25239
PURE UUID: e2fc3dfa-64e3-4dcf-921b-542d4afa4bce

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 22 Jul 2022 20:30

Export record

Contributors

Author: D.J.P. Barker

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×