Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children
Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children
Aim: To investigate the relationship between anthropometry at birth and glucose/insulin metabolism in childhood using the response to an oral glucose challenge.
Method: Four hundred mother/child pairs on whom gestational and birth data were available were studied. After an overnight fast, anthropometric measurements were made on the children and an oral glucose tolerance test performed. The plasma concentrations of insulin, pro-insulin and 32-33 split pro-insulin were also measured. Skinfold thicknesses were used to calculate percentage body fat and fat mass was derived from the percentage fat and absolute weight.
Results: The mean age of the children was 8 y (range 7.5-10.5), and six exhibited impaired glucose tolerance based on WHO criteria. Insulin concentration 120 min after the oral glucose load (a measure of insulin resistance) was inversely related to length at birth (P<0.005). The children who were in the shortest quartile at birth and were heaviest at 8 y old had the highest insulin concentration.
Conclusion: Shortness at birth is related to insulin resistance. Such insensitivity to the action of insulin is greater in heavier children.
type 2 diabetes mellitus, crown-heel length, insulin resistance
506-511
Bennett, F.
97d3c5e8-0d95-4964-b062-2981bc35ad5b
Watson-Brown, C.
949972b3-e8ff-43c7-8648-112770a07d87
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Wilks, R.
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Osmond, C.
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Hales, N.
043432d9-43ba-453f-81d5-a68cde6d02d2
Barker, D.
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Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3
2002
Bennett, F.
97d3c5e8-0d95-4964-b062-2981bc35ad5b
Watson-Brown, C.
949972b3-e8ff-43c7-8648-112770a07d87
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Wilks, R.
22c87940-6326-4e9b-9b67-637c14baaa5b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Hales, N.
043432d9-43ba-453f-81d5-a68cde6d02d2
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3
Bennett, F., Watson-Brown, C., Thame, M., Wilks, R., Osmond, C., Hales, N., Barker, D. and Forrester, T.
(2002)
Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children.
European Journal of Clinical Nutrition, 56 (6), .
(doi:10.1038/sj.ejcn.1601339).
Abstract
Aim: To investigate the relationship between anthropometry at birth and glucose/insulin metabolism in childhood using the response to an oral glucose challenge.
Method: Four hundred mother/child pairs on whom gestational and birth data were available were studied. After an overnight fast, anthropometric measurements were made on the children and an oral glucose tolerance test performed. The plasma concentrations of insulin, pro-insulin and 32-33 split pro-insulin were also measured. Skinfold thicknesses were used to calculate percentage body fat and fat mass was derived from the percentage fat and absolute weight.
Results: The mean age of the children was 8 y (range 7.5-10.5), and six exhibited impaired glucose tolerance based on WHO criteria. Insulin concentration 120 min after the oral glucose load (a measure of insulin resistance) was inversely related to length at birth (P<0.005). The children who were in the shortest quartile at birth and were heaviest at 8 y old had the highest insulin concentration.
Conclusion: Shortness at birth is related to insulin resistance. Such insensitivity to the action of insulin is greater in heavier children.
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More information
Published date: 2002
Keywords:
type 2 diabetes mellitus, crown-heel length, insulin resistance
Identifiers
Local EPrints ID: 25248
URI: http://eprints.soton.ac.uk/id/eprint/25248
ISSN: 0954-3007
PURE UUID: 089255ea-d21e-4e1c-acc3-c591398a5143
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Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 02:50
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Contributors
Author:
F. Bennett
Author:
C. Watson-Brown
Author:
M. Thame
Author:
R. Wilks
Author:
N. Hales
Author:
D. Barker
Author:
T. Forrester
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