The University of Southampton
University of Southampton Institutional Repository

Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children

Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children
Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children
Aim: To investigate the relationship between anthropometry at birth and glucose/insulin metabolism in childhood using the response to an oral glucose challenge.
Method: Four hundred mother/child pairs on whom gestational and birth data were available were studied. After an overnight fast, anthropometric measurements were made on the children and an oral glucose tolerance test performed. The plasma concentrations of insulin, pro-insulin and 32-33 split pro-insulin were also measured. Skinfold thicknesses were used to calculate percentage body fat and fat mass was derived from the percentage fat and absolute weight.
Results: The mean age of the children was 8 y (range 7.5-10.5), and six exhibited impaired glucose tolerance based on WHO criteria. Insulin concentration 120 min after the oral glucose load (a measure of insulin resistance) was inversely related to length at birth (P<0.005). The children who were in the shortest quartile at birth and were heaviest at 8 y old had the highest insulin concentration.
Conclusion: Shortness at birth is related to insulin resistance. Such insensitivity to the action of insulin is greater in heavier children.
type 2 diabetes mellitus, crown-heel length, insulin resistance
0954-3007
506-511
Bennett, F.
97d3c5e8-0d95-4964-b062-2981bc35ad5b
Watson-Brown, C.
949972b3-e8ff-43c7-8648-112770a07d87
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Wilks, R.
22c87940-6326-4e9b-9b67-637c14baaa5b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Hales, N.
043432d9-43ba-453f-81d5-a68cde6d02d2
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3
Bennett, F.
97d3c5e8-0d95-4964-b062-2981bc35ad5b
Watson-Brown, C.
949972b3-e8ff-43c7-8648-112770a07d87
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Wilks, R.
22c87940-6326-4e9b-9b67-637c14baaa5b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Hales, N.
043432d9-43ba-453f-81d5-a68cde6d02d2
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
Forrester, T.
84984e0d-1dd5-479c-91ed-b3d9c0fbd9d3

Bennett, F., Watson-Brown, C., Thame, M., Wilks, R., Osmond, C., Hales, N., Barker, D. and Forrester, T. (2002) Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children. European Journal of Clinical Nutrition, 56 (6), 506-511. (doi:10.1038/sj.ejcn.1601339).

Record type: Article

Abstract

Aim: To investigate the relationship between anthropometry at birth and glucose/insulin metabolism in childhood using the response to an oral glucose challenge.
Method: Four hundred mother/child pairs on whom gestational and birth data were available were studied. After an overnight fast, anthropometric measurements were made on the children and an oral glucose tolerance test performed. The plasma concentrations of insulin, pro-insulin and 32-33 split pro-insulin were also measured. Skinfold thicknesses were used to calculate percentage body fat and fat mass was derived from the percentage fat and absolute weight.
Results: The mean age of the children was 8 y (range 7.5-10.5), and six exhibited impaired glucose tolerance based on WHO criteria. Insulin concentration 120 min after the oral glucose load (a measure of insulin resistance) was inversely related to length at birth (P<0.005). The children who were in the shortest quartile at birth and were heaviest at 8 y old had the highest insulin concentration.
Conclusion: Shortness at birth is related to insulin resistance. Such insensitivity to the action of insulin is greater in heavier children.

Full text not available from this repository.

More information

Published date: 2002
Keywords: type 2 diabetes mellitus, crown-heel length, insulin resistance

Identifiers

Local EPrints ID: 25248
URI: http://eprints.soton.ac.uk/id/eprint/25248
ISSN: 0954-3007
PURE UUID: 089255ea-d21e-4e1c-acc3-c591398a5143
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 18 Feb 2021 16:45

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×